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We present leakage-free valves and an efficient fixed-volume mixer fabricated using a four-layer soft lithography technique in polydimethylsiloxane (PDMS). Mixing is achieved with a 95% efficiency in a few seconds by creating circular flow patterns inside a simple rectangular chamber. Pressurized air is used to actuate control chambers for active valving and mixing. In our device, neither the mold nor the microfluidic channel requires complex designs.
Sophia Haussener, Esther Amstad, Gaia De Angelis, Swarnava Nandy, Sangram Ashok Savant