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IMPORTANCE Aging is associated with a decline in mitochondrial function and reduced exercise capacity. Urolithin A is a natural gut microbiome-derived food metabolite that has been shown to stimulate mitophagy and improve muscle function in older animals and to induce mitochondrial gene expression in older humans.
Johan Auwerx, Davide D'Amico, Pénélope Andreux, Tanes Imamura de Lima, Martin Rainer Wohlwend, Pirkka-Pekka Untamo Laurila, Peiling Luan