High bi-atrial organization in patients with long-standing persistent atrial fibrillation terminated within the left atrium

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p-Aminobenzamidine attenuates cardiovascular dysfunctions in spontaneously hypertensive rats

Nikolaos Stergiopoulos, Fabiana Pereira Da Costa Fraga, Allancer Divino De Carvalho Nunes

Aims:Diminazene aceturate, a putative ACE2 activator, is susceptible to cleavage resulting in the formation of paminobenzamidine (PAB). This study aimed to investigate the effects of PAB in addressing cardiovascular dysfunctions in spontaneously hypertensi ...

PERGAMON-ELSEVIER SCIENCE LTD2022

ECG-Based Indices to Characterize Persistent Atrial Fibrillation Before and During Stepwise Catheter Ablation

Jean-Marc Vesin, Etienne Pruvot, Adrian Luca

Background: Consistently successful patient outcomes following catheter ablation (CA) for treatment of persistent atrial fibrillation (pers-AF) remain elusive. We propose an electrocardiogram (ECG) analysis designed to (1) refine selection of patients most ...

2021

Dynamics of Intraprocedural Dominant Frequency Identifies Ablation Outcome in Persistent Atrial Fibrillation

Jean-Marc Vesin, Andréa Buttu, Etienne Pruvot, Alain Pithon, Adrian Luca

Background: The role of dominant frequency (DF) in tracking the efficiency of a stepwise catheter ablation (step-CA) in persistent atrial fibrillation (peAF) remains poorly studied. We hypothesized that the DF time-course during step-CA displays divergent ...

2021

Association of Heart Rate Variability With Silent Brain Infarcts in Patients With Atrial Fibrillation

Vincent Schlageter, Jean-Marc Vesin

Purpose: Silent brain infarcts (SBI) are frequently detected in patients with atrial fibrillation (AF), but it is unknown whether SBI are linked to autonomic dysfunction. We aimed to explore the association of autonomic dysfunction with SBI in AF patients. ...

FRONTIERS MEDIA SA2021

A Computational Study of the Electrophysiological Substrate in Patients Suffering From Atrial Fibrillation

Alfio Quarteroni, Andrea Manzoni

In the context of cardiac electrophysiology, we propose a novel computational approach to highlight and explain the long-debated mechanisms behind atrial fibrillation (AF) and to reliably numerically predict its induction and sustainment. A key role is pla ...

FRONTIERS MEDIA SA2021

In vivo application and validation of a novel noninvasive method to estimate the end-systolic elastance

Nikolaos Stergiopoulos, Stamatia Zoi Pagoulatou, Vasiliki Bikia, Georgios Rovas

Accurate assessment of the left ventricular (LV) systolic function is indispensable in the clinic. However, estimation of a precise index of cardiac contractility, i.e., the end-systolic elastance (E-es), is invasive and cannot be established as clinical r ...

2021

Implantable Fiber Bragg Grating Sensor for Continuous Heart Activity Monitoring: Ex-Vivo and In-Vivo Validation

Silvestro Micera

Continuous and reliable cardiac function monitoring could improve medication adherence in patients at risk of heart failure. This work presents an innovative implantable Fiber Bragg Grating-based soft sensor designed to sense mechanical cardiac activity. T ...

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC2021

Acute and Long-Term Effects of Aortic Compliance Decrease on Central Hemodynamics: A Modeling Analysis

Nikolaos Stergiopoulos, Stamatia Zoi Pagoulatou, Vasiliki Bikia, Georgios Rovas

Aortic compliance is an important determinant of cardiac afterload and a contributor to cardiovascular morbidity. In the present study, we sought to provide in silico insights into the acute as well as long-term effects of aortic compliance decrease on cen ...

FRONTIERS MEDIA SA2021

Estimation of Left Ventricular End-Systolic Elastance From Brachial Pressure Waveform via Deep Learning

Nikolaos Stergiopoulos, Stamatia Zoi Pagoulatou, Vasiliki Bikia, Marija Lazaroska, Georgios Rovas

Determination of left ventricular (LV) end-systolic elastance (E- es ) is of utmost importance for assessing the cardiac systolic function and hemodynamical state in humans. Yet, the clinical use of E- es is not established due to the invasive nature and h ...

FRONTIERS MEDIA SA2021

Movement-Related Cortical Potentials in Embodied Virtual Mirror Visual Feedback

Gangadhar Garipelli, Tamara Rossy

Background: Mirror therapy is thought to drive interhemispheric communication, resulting in a balanced activation. We hypothesized that embodied virtual mirror visual feedback (VR-MVF) presented on a computer screen may produce a similar activation. In thi ...

FRONTIERS MEDIA SA2021

Computational methods for live heart imaging with speed-constrained microscopes

Olivia Mariani

Imaging methods to capture the beating and developing heart inside embryonic animal models such as the zebrafish are a key component for the study of fundamental biological processes such as cardiac birth defects or tissue regeneration. However, live heart ...

EPFL2021

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