Publication

Mathematical modeling of bone formation inside tissue engineering scaffolds (Master project)

2010
Student Projects

Abstract

Tissue engineering scaffolds are porous structures that allow bone cells to reside and produce bone. This process involves migration and differentiation of mesenchymal stromal cells and production of cartilage and bone by chondrocytes and osteoblasts, which is basically a bone healing process. Based on a mechanistic model of fracture healing, a 2D model of bone formation inside scaffold will be developed. Extensive experimental data from an in vivo study is available which will be used to verify the results of this mathematical model. This project demands working with MATLAB and COMSOL. A good mathematical background is highly recommended.

Official source

https://infoscience.epfl.ch/entities/publication/93082b75-f4fb-48f6-89a1-62be786be9ed

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2010
Student Projects

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/93082b75-f4fb-48f6-89a1-62be786be9ed

About this result

Related concepts (32)

Bone

A bone is a rigid organ that constitutes part of the skeleton in most vertebrate animals. Bones protect the various other organs of the body, produce red and white blood cells, store minerals, provide structure and support for the body, and enable mobility. Bones come in a variety of shapes and sizes and have complex internal and external structures. They are lightweight yet strong and hard and serve multiple functions. Bone tissue (osseous tissue), which is also called bone in the uncountable sense of that word, is hard tissue, a type of specialised connective tissue.

Bone healing

Bone healing, or fracture healing, is a proliferative physiological process in which the body facilitates the repair of a bone fracture. Generally, bone fracture treatment consists of a doctor reducing (pushing) displaced bones back into place via relocation with or without anaesthetic, stabilizing their position to aid union, and then waiting for the bone's natural healing process to occur. Adequate nutrient intake has been found to significantly affect the integrity of the fracture repair.

Bone fracture

A bone fracture (abbreviated FRX or Fx, Fx, or #) is a medical condition in which there is a partial or complete break in the continuity of any bone in the body. In more severe cases, the bone may be broken into several fragments, known as a comminuted fracture. A bone fracture may be the result of high force impact or stress, or a minimal trauma injury as a result of certain medical conditions that weaken the bones, such as osteoporosis, osteopenia, bone cancer, or osteogenesis imperfecta, where the fracture is then properly termed a pathologic fracture.

Related publications (18)

Mathematical modeling of bone formation inside tissue engineering scaffolds (Master project)

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