TMX4-driven LINC complex disassembly and asymmetric autophagy of the nuclear envelope upon acute ER stress

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Two fundamental properties of embryonic stem cells (ESCs) are their ability to self-renew and differentiate into all somatic cell types. Maintenance of their identity faces major challenges when transitioning through mitosis, as most DNA-binding proteins a ...

Proteins are the basic building blocks necessary for the operation and regulation of virtually all functions in living organisms. Over millions of years, evolution has created a vast repertoire of proteins finely tuned to execute their biological functions ...

The organisation of molecules into dynamic cells, and collaboration of many of those cells over a billion years led to the evolution of human life. During the last century, biologists then began to unravel the marvels of cellular organisation with ever inc ...

Regulation of gene expression is essential for the functioning of all eukaryotic organisms. Understanding gene expression regulation requires determining which proteins interact with regulatory elements in chromatin. MS-based analysis of chromatin has emer ...

Duchenne muscular dystrophy (DMD) is the most common muscular dystrophy, and despite advances in genetic and pharmacological disease-modifying treatments, its management remains a major challenge. Mitochondrial dysfunction contributes to DMD, yet the mecha ...

Mechanobiology explores how forces regulate cell behaviors and what molecular machinery are responsible for the sensing, transduction, and modulation of mechanical cues. To this end, probing of cells cultured on planar substrates has served as a primary ex ...

Phase separation of immiscible fluids is a common phenomenon in polymer chemistry, and is recognized as an important mechanism by which cells compartmentalize their biochemical reactions. Biomolecular condensates are condensed fluid droplets in cells that ...

Some sacoglossan sea slugs incorporate intracellular functional algal chloroplasts, a process termed kleptoplasty. "Stolen" chloroplasts (kleptoplasts) can remain photosynthetically active up to several months, contributing to animal nutrition. Whether thi ...

This study demonstrates that the aerodynamic drag profile of a patterned deformable cylinder at high Reynolds numbers can be programmed, on demand, by modifying its topography through pneumatic actuation. The samples used in the experiments comprise a rigi ...

TMX4-driven LINC complex disassembly and asymmetric autophagy of the nuclear envelope upon acute ER stress

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Deciphering the molecular events leading to the global restoration of the chromatin landscape during mitotic exit

Targeting molecular surfaces to engineer novel protein-based immunogens and inhibitors

Organisation and dynamics of mitochondria and their RNA

Chromatin Proteomics to Study Epigenetics - Challenges and Opportunities

Urolithin A improves muscle function by inducing mitophagy in muscular dystrophy

Engineered Extracellular Matrices with Integrated Wireless Microactuators to Study Mechanobiology

Phase behaviour and structure of a model biomolecular condensate

Functional kleptoplasts intermediate incorporation of carbon and nitrogen in cells of the Sacoglossa sea slug Elysia viridis

Editorial overview: The future after the cryo-EM resolution revolution

Programmable Aerodynamic Drag on Active Dimpled Cylinders