Targeting the Progesterone Receptor in Breast Cancer: Mind the Short Form!

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The hallmarks of cancer conceptualization is a heuristic tool for distilling the vast complexity of cancer phenotypes and genotypes into a provisional set of underl y-ing principles. As knowledge of cancer mechanisms has progressed, other facets of the dis ...

Automated fact-checking is a needed technology to curtail the spread of online misinformation. One current framework for such solutions proposes to verify claims by retrieving supporting or refuting evidence from related textual sources. However, the reali ...

Solid cancers exhibit a dynamic balance between cell death and proliferation ensuring continuous tumour maintenance and growth(1,2). Increasing evidence links enhanced cancer cell apoptosis to paracrine activation of cells in the tumour microenvironment in ...

Compared to estrogen receptor-negative (ER-) breast cancer (BC), ER+ BC often manifests with a latent disease that recurs decades after initial diagnosis. The mechanisms governing dormancy and distant recurrence of ER+ tumors remain elusive due to the lack ...

Estrogen hormones are implicated in a majority of breast cancers and estrogen receptor alpha (ER), the main nuclear factor mediating estrogen signaling, orchestrates a complex molecular circuitry that is not yet fully elucidated. Here, we investigated geno ...

Motivated by the goal of designing interventions for softening polarized opinions on the Web, and building on results from psychology, we hypothesized that people would be moved more easily towards opposing opinions when the latter were voiced by a celebri ...

Whereas electron-phonon scattering relaxes the electron's momentum in metals, a perpetual exchange of momentum between phonons and electrons may conserve total momentum and lead to a coupled electron-phonon liquid. Such a phase of matter could be a platfor ...

Exposure to daylight has much to offer and should be optimised to maximise its potential. In order to harvest its benefits, any visual discomfort from daylight should be anticipated and minimised. Hence, there is the need to predict discomfort from dayligh ...

Invasive lobular carcinoma (ILC) is the most frequent special histological subtype of breast cancer, typically characterized by loss of E‐cadherin. It has clinical features distinct from other estrogen receptor‐positive (ER+) breast cancers but the molecul ...

Genotype imputation is a fundamental step in genomic data analysis, where missing variant genotypes are predicted using the existing genotypes of nearby "tag"variants. Although researchers can outsource genotype imputation, privacy concerns may prohibit ge ...

Cancer represents one of the major public health challenges worldwide, representing more than 25% of all deaths in the European Union in 2014. It affects a large and growing part of the general population, with the National Cancer Institute (NCI) estimatin ...

17 beta-Estradiol induces the postnatal development of mammary gland and influences breast carcinogenesis by binding to the estrogen receptor ER alpha. ER alpha acts as a transcription factor but also elicits rapid signaling through a fraction of ER alpha ...

Targeting the Progesterone Receptor in Breast Cancer: Mind the Short Form!

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Hallmarks of Cancer: New Dimensions

Synthetic Disinformation Attacks on Automated Fact Verification Systems

Colon tumour cell death causes mTOR dependence by paracrine P2X4 stimulation

Intraductal xenografts model estrogen receptor-positive (ER+) breast cancer dormancy and reveal a critical role for epithelial-mesenchymal transition (EMT) in its establishment

Epigenetic remodelling of enhancers in response to estrogen deprivation and re-stimulation

Interventions for Softening Can Lead to Hardening of Opinions: Evidence from a Randomized Controlled Trial

Evidence of a coupled electron-phonon liquid in NbGe2

Is there a difference in how people from different socio-environmental contexts perceive discomfort due to glare from daylight?

Intraductal xenografts show lobular carcinoma cells rely on their own extracellular matrix and LOXL1

Ultrafast homomorphic encryption models enable secure outsourcing of genotype imputation

An autonomous microfluidic device for identification and analysis of individual clinically-relevant mammalian cells

Membrane expression of the estrogen receptor ER alpha is required for intercellular communications in the mammary epithelium