Publication

Para-Selective Gold-Catalyzed Direct Alkynylation of Anilines

Jérôme Waser, Jonathan Brand
2012
Journal Articles

Abstract

A method for the para-selective alkynylation of anilines is reported using AuCl as catalyst and triisopropylsilylethynyl-1,2-benziodoxol-3(1H)-one (TIPS-EBX) as an electrophilic acetylene equivalent. Para-alkynyl anilines substituted at positions 2 or 3 were obtained in one step from simple anilines under mild conditions (room temperature to 60 degrees C) under air. The methodology could also be extended to the alkynylation of trimethoxybenzenes.

Official source

https://infoscience.epfl.ch/entities/publication/90712efc-be0d-4999-92ee-b339f4dd9a6a

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Para-Selective Gold-Catalyzed Direct Alkynylation of Anilines

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