Publication

Regional changes in NGF receptor immunohistochemical labeling in the septum of the aged rat

1990
Journal Articles

Abstract

A monoclonal antibody to the nerve growth factor receptor (NGFR) (IgG 192) was used to visualize differences in immunohistochemical labeling of young (10 months) and old (35 months) rats. Three parameters were analyzed; cell counts, immunoreactive cross-sectional surface area (SA) and optical density (OD) of labeled cells. Large reductions in all three parameters were recorded in the medial septum (MS). Both OD and immunoreactive SA were reduced in the VDB, while only OD was reduced in the HDB. This observation confirms that NGFR labeling is reduced in the aged rat septum and adds that the loss of labeling is differential, with greater deficits in the MS-VDB complex than in the HDB.

Official source

https://infoscience.epfl.ch/entities/publication/8ff5cb98-b1d9-465f-a8be-13647f773794

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1990
Journal Articles

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/8ff5cb98-b1d9-465f-a8be-13647f773794

About this result

Related concepts (32)

Laboratory rat

Laboratory rats or lab rats are strains of the subspecies Rattus norvegicus domestica which are bred and kept for scientific research. While less commonly used for research than laboratory mice, rats have served as an important animal model for research in psychology and biomedical science. In 18th century Europe, wild brown rats (Rattus norvegicus) ran rampant and this infestation fueled the industry of rat-catching. Rat-catchers would not only make money by trapping the rodents, but also by selling them for food or, more commonly, for rat-baiting.

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Related publications (1)

Regional changes in NGF receptor immunohistochemical labeling in the septum of the aged rat

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