Plaque-prone hemodynamics impair endothelial function in pig carotid arteries

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p-Aminobenzamidine attenuates cardiovascular dysfunctions in spontaneously hypertensive rats

Nikolaos Stergiopoulos, Fabiana Pereira Da Costa Fraga, Allancer Divino De Carvalho Nunes

Aims:Diminazene aceturate, a putative ACE2 activator, is susceptible to cleavage resulting in the formation of paminobenzamidine (PAB). This study aimed to investigate the effects of PAB in addressing cardiovascular dysfunctions in spontaneously hypertensi ...

PERGAMON-ELSEVIER SCIENCE LTD2022

Effects of velocity-dependent apparent toughness on the pre- and post-shut-in growth of a hydraulic fracture

Dong Liu, Guanyi Lu

We investigate the growth of a plane-strain/radial hydraulic fracture in an infinite impermeable medium driven by a constant injection rate assuming that the apparent toughness scales with the decreasing fracture growth rate in a power-law relation. The vi ...

ELSEVIER SCI LTD2022

Impact and implications of mixed plaque class in automated characterization of complex atherosclerotic lesions

Yanan Niu

Atherosclerosis is a complex disease altering vasculature morphology, and subsequently flow, with progressive plaque formation, mural disruption, and lumen occlusion. Determination of clinically-relevant plaque components-particularly calcium, lipid, and f ...

PERGAMON-ELSEVIER SCIENCE LTD2022

Weakening effect of various pore fluids on the tensile strength of granite

Guanyi Lu

Laboratory three-point bending experiments are carried out to evaluate the effect of various fluids on the tensile strength of granite. The granite specimens were tested under both dry and saturated conditions. The fluids used to saturate the granite inclu ...

SPRINGER HEIDELBERG2022

Sodium thiosulfate, a source of hydrogen sulfide, stimulates endothelial cell proliferation and neovascularization

Georges Wagnières, Séverine Marguerite Urfer, Jaroslava Joniová

Therapies to accelerate vascular repair are currently lacking. Pre-clinical studies suggest that hydrogen sulfide (H2S), an endogenous gasotransmitter, promotes angiogenesis. Here, we hypothesized that sodium thiosulfate (STS), a clinically relevant source ...

FRONTIERS MEDIA SA2022

Current challenges in understanding the role of enhancers in disease

Bart Deplancke

Enhancers play a central role in the spatiotemporal control of gene expression and tend to work in a cell-type-specific manner. In addition, they are suggested to be major contributors to phenotypic variation, evolution and disease. There is growing eviden ...

NATURE PORTFOLIO2022

Fiber Buckling in Confined Viscous Flows: An Absolute Instability Described by the Linear Ginzburg-Landau Equation

François Gallaire, Jean Cappello

We explore the dynamics of a flexible fiber transported by a viscous flow in a Hele-Shaw cell of height comparable to the fiber height. We show that long fibers aligned with the flow experience a buckling instability. Competition between viscous and elasti ...

AMER PHYSICAL SOC2022

An Implantable Inductive Sensor for Direct and Continuous Monitoring of the Pulmonary Artery Cross-Sectional Area

Marco Mattavelli, Catherine Dehollain, Diego Ruben Barrettino, Kerim Türe, Mustafa Besirli

This paper presents a novel method for the measure of the cross-sectional area (CSA) of an artery to be used for the direct and continuous (24/7) monitoring of cardiac output (CO). The method is based on the inductance change of an anchoring loop mounted o ...

IEEE2022

Effects of the parallel flow shear on the ITG-driven turbulent transport in tokamak plasmas

Yann Camenen, Javier García Hernández, Samuele Mazzi

The impact of the parallel flow shear on the tokamak plasma stability and turbulent transport driven by the ion temperature gradient (ITG) modes is analyzed by means of local gyrokinetic numerical analyses. It is shown that the parallel flow shear increase ...

IOP Publishing Ltd2022

Transposable elements contribute to the spatiotemporal microRNA landscape in human brain development

Didier Trono, Shaoline Sheppard, Evaristo Jose Planet Letschert, Christopher James Playfoot

Transposable elements (TEs) contribute to the evolution of gene regulatory networks and are dynamically expressed throughout human brain development and disease. One gene regulatory mechanism influenced by TEs is the miRNA system of post-transcriptional co ...

2022

Scaling Description of Creep Flow in Amorphous Solids

Marko Popovic, Matthieu Wyart, Wencheng Ji, Thomas Willem Jan de Geus

Amorphous solids such as coffee foam, toothpaste, or mayonnaise display a transient creep flow when a stress E is suddenly imposed. The associated strain rate is commonly found to decay in time as gamma_ -t-nu, followed either by arrest or by a sudden flui ...

AMER PHYSICAL SOC2022

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