Publication

Influence of Right and Left Atrial Tissue Heterogeneity on Atrial Fibrillation Perpetuation

Jean-Marc Vesin
2015
Conference Papers

Abstract

We propose a biophysical modelling approach to separately investigate the impact of right and left atrial (RA/LA) electrical heterogeneity on atrial fibrillation (AF) perpetuation. The baseline AF substrate was based on a 4:1 anisotropy ratio and uniform membrane properties. AF was initiated by a ramp-pacing protocol applied in the pulmonary veins region. Once AF was observed, random patchy heterogeneities in action potential duration (shorter duration inside the patches) were introduced in the cellular model for the subsequent simulation of AF. The effect of tissue heterogeneity on AF perpetuation was quantified by the duration of AF episodes (an AF episode lasting more than 50 s was considered as sustained). For high percentages of heterogeneities, the mean AF episode duration and the number of non-terminated AF episodes were significantly higher for the RA compared to the LA. This could be indicative of a very probable involvement of the RA substrate into the persistent AF process in this model. A direct link between the spatial localization of tissue heterogeneity and AF duration was also observed.

Official source

https://infoscience.epfl.ch/entities/publication/8e76b79c-f11b-46ad-a43c-4363e9be3ab7

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Jean-Marc Vesin
2015
Conference Papers

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/8e76b79c-f11b-46ad-a43c-4363e9be3ab7

About this result

Related concepts (30)

Atrial fibrillation

Atrial fibrillation (AF or A-fib) is an abnormal heart rhythm (arrhythmia) characterized by rapid and irregular beating of the atrial chambers of the heart. It often begins as short periods of abnormal beating, which become longer or continuous over time. It may also start as other forms of arrhythmia such as atrial flutter that then transform into AF. Episodes can be asymptomatic. Symptomatic episodes may involve heart palpitations, fainting, lightheadedness, shortness of breath, or chest pain.

Atrial flutter

Atrial flutter (AFL) is a common abnormal heart rhythm that starts in the atrial chambers of the heart. When it first occurs, it is usually associated with a fast heart rate and is classified as a type of supraventricular tachycardia. Atrial flutter is characterized by a sudden-onset (usually) regular abnormal heart rhythm on an electrocardiogram (ECG) in which the heart rate is fast. Symptoms may include a feeling of the heart beating too fast, too hard, or skipping beats, chest discomfort, difficulty breathing, a feeling as if one's stomach has dropped, a feeling of being light-headed, or loss of consciousness.

Ventricular fibrillation

Ventricular fibrillation (V-fib or VF) is an abnormal heart rhythm in which the ventricles of the heart quiver. It is due to disorganized electrical activity. Ventricular fibrillation results in cardiac arrest with loss of consciousness and no pulse. This is followed by sudden cardiac death in the absence of treatment. Ventricular fibrillation is initially found in about 10% of people with cardiac arrest. Ventricular fibrillation can occur due to coronary heart disease, valvular heart disease, cardiomyopathy, Brugada syndrome, long QT syndrome, electric shock, or intracranial hemorrhage.

Related publications (1)

Influence of Right and Left Atrial Tissue Heterogeneity on Atrial Fibrillation Perpetuation

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Prediction of Atrial Fibrillation Termination by Catheter Ablation Using Adaptive Frequency Tracking of Atrial ECG Signal