Publication

Sustained Effects of Nonallele-Specific Huntingtin Silencing

Ruth Luthi-Carter
2009
Journal Articles

Abstract

Objective: Huntington's disease (HD) is a fatal autosomal dominant neurodegenerative disorder caused by a polyglutamine expansion in the huntingtin (htt) protein. No cure is available to date to alleviate neurodegeneration. Recent studies have demonstrated that RNA interference represents a promising approach for the treatment of autosomal dominant disorders. But whether an allele-specific silencing of mutant htt or a nonallele-specific silencing should be considered has not been addressed.

Official source

https://infoscience.epfl.ch/entities/publication/8c887cad-69fa-481f-80fc-2b1a350c92df

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Sustained Effects of Nonallele-Specific Huntingtin Silencing

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