Publication

Towards the accurate measurement of internuclear distances in biological macromolecules by suppression of spin diffusion

Geoffrey Bodenhausen
1996
Conference Papers

Abstract

The anal. of 2-dimensional NOESY spectra can be misleading if spin diffusion effects are not properly taken into account. An approach consisting in suppressing spin diffusion by selective inversion of the spins undergoing the Overhauser effect, known as QUIET-NOESY (Zwahlen, C. et al., 1994), is described. In addn., the QUIET-EXSY method (Zwahlen, C. et al., 1995), related to the suppression of spin diffusion by QUIET-NOESY, is discussed. [on SciFinder (R)]

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Geoffrey Bodenhausen
1996
Conference Papers

Abstract

Official source

Related concepts (22)

Nuclear Overhauser effect

The nuclear Overhauser effect (NOE) is the transfer of nuclear spin polarization from one population of spin-active nuclei (e.g. 1H, 13C, 15N etc.) to another via cross-relaxation. A phenomenological definition of the NOE in nuclear magnetic resonance spectroscopy (NMR) is the change in the integrated intensity (positive or negative) of one NMR resonance that occurs when another is saturated by irradiation with an RF field. The change in resonance intensity of a nucleus is a consequence of the nucleus being close in space to those directly affected by the RF perturbation.

Nuclear magnetic resonance spectroscopy

Nuclear magnetic resonance spectroscopy, most commonly known as NMR spectroscopy or magnetic resonance spectroscopy (MRS), is a spectroscopic technique to observe local magnetic fields around atomic nuclei. This spectroscopy is based on the measurement of absorption of electromagnetic radiations in the radio frequency region from roughly 4 to 900 MHz. Absorption of radio waves in the presence of magnetic field is accompanied by a special type of nuclear transition, and for this reason, such type of spectroscopy is known as Nuclear Magnetic Resonance Spectroscopy.

Two-dimensional nuclear magnetic resonance spectroscopy

Two-dimensional nuclear magnetic resonance spectroscopy (2D NMR) is a set of nuclear magnetic resonance spectroscopy (NMR) methods which give data plotted in a space defined by two frequency axes rather than one. Types of 2D NMR include correlation spectroscopy (COSY), J-spectroscopy, exchange spectroscopy (EXSY), and nuclear Overhauser effect spectroscopy (NOESY). Two-dimensional NMR spectra provide more information about a molecule than one-dimensional NMR spectra and are especially useful in determining the structure of a molecule, particularly for molecules that are too complicated to work with using one-dimensional NMR.

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Towards the accurate measurement of internuclear distances in biological macromolecules by suppression of spin diffusion

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