Publication

Weiche elektrochemische Sonden zum Abbilden der Verteilung von Biomarkern und injizierten Nanomaterialien in tierischem und menschlichem Gewebe

Hubert Girault, Horst Pick, Andreas Stephan Lesch, Tzu-En Lin
2017
Journal Articles

Abstract

Die Untersuchung von Biomarkern und injizierten theranostischen Nanomaterialien in Geweben und Organen spielt eine zentrale Rolle bei zahlreichen medizinischen Verfahren von der Krebsdiagnose bis hin zur Arzneimittelverabreichung. Zu diesem Zweck kann die elektrochemische Rastersondenmikroskopie hochaufgelöste Abbildungen der räumlichen Verteilung von wichtigen Biomolekülen ohne optische Interferenzen liefern. Wir haben weiche Mikroelektroden zum Abtasten großflächiger und dicker Gewebeschnitte und Organe, die in eine Elektrolytlösung eingetaucht sind, verwendet. Die Messung amperometrischer Ströme wurde durch den lokalen Fluss redoxaktiver Spezies ermöglicht, welche lokal und spezifisch durch Biomarker und Nanomaterialien in den Proben erzeugt wurden. Die biologischen Verteilungen von Graphenoxidnanostreifen in Mäuseleber, von prognostischen Proteinbiomarkern in menschlichem Hautkrebsgewebe und von redoxaktiven Proteinen in Mäuseherzen wurden separat abgebildet.

Official source

https://infoscience.epfl.ch/entities/publication/897c3be3-79ec-482d-a2a7-dd4ab6338d90

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Hubert Girault, Horst Pick, Andreas Stephan Lesch, Tzu-En Lin
2017
Journal Articles

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/897c3be3-79ec-482d-a2a7-dd4ab6338d90

About this result

Related concepts (3)

Die casting

Die casting is a metal casting process that is characterized by forcing molten metal under high pressure into a mold cavity. The mold cavity is created using two hardened tool steel dies which have been machined into shape and work similarly to an injection mold during the process. Most die castings are made from non-ferrous metals, specifically zinc, copper, aluminium, magnesium, lead, pewter, and tin-based alloys. Depending on the type of metal being cast, a hot- or cold-chamber machine is used.

Die (manufacturing)

A die is a specialized machine tool used in manufacturing industries to cut and/or form material to a desired shape or profile. Stamping dies are used with a press, as opposed to drawing dies (used in the manufacture of wire) and casting dies (used in molding) which are not. Like molds, dies are generally customized to the item they are used to create. Products made with dies range from simple paper clips to complex pieces used in advanced technology.

Tool and die maker

Tool and die makers are highly skilled crafters working in the manufacturing industries. Variations on the name include tool maker, toolmaker, die maker, diemaker, mold maker, moldmaker or tool jig and die-maker depending on which area of concentration or industry an individual works in. Tool and die makers work primarily in toolroom environments—sometimes literally in one room but more often in an environment with flexible, semipermeable boundaries from production work.