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A search for heavy neutral lepton (N) production in π+→e+N in-flight decays using data collected by the NA62 experiment at CERN in 2017–2024 is reported. Upper limits for the extended neutrino mixing matrix element |Ue4|2 are established at the level of 10−8 for heavy neutral leptons with mass in the range 95–126 MeV/c2 and lifetime exceeding 50 ns.