MutationIn biology, a mutation is an alteration in the nucleic acid sequence of the genome of an organism, virus, or extrachromosomal DNA. Viral genomes contain either DNA or RNA. Mutations result from errors during DNA or viral replication, mitosis, or meiosis or other types of damage to DNA (such as pyrimidine dimers caused by exposure to ultraviolet radiation), which then may undergo error-prone repair (especially microhomology-mediated end joining), cause an error during other forms of repair, or cause an error during replication (translesion synthesis).
Nearly neutral theory of molecular evolutionThe nearly neutral theory of molecular evolution is a modification of the neutral theory of molecular evolution that accounts for the fact that not all mutations are either so deleterious such that they can be ignored, or else neutral. Slightly deleterious mutations are reliably purged only when their selection coefficient are greater than one divided by the effective population size. In larger populations, a higher proportion of mutations exceed this threshold for which genetic drift cannot overpower selection, leading to fewer fixation events and so slower molecular evolution.
Negative selection (natural selection)In natural selection, negative selection or purifying selection is the selective removal of alleles that are deleterious. This can result in stabilising selection through the purging of deleterious genetic polymorphisms that arise through random mutations. Purging of deleterious alleles can be achieved on the population genetics level, with as little as a single point mutation being the unit of selection. In such a case, carriers of the harmful point mutation have fewer offspring each generation, reducing the frequency of the mutation in the gene pool.
Muller's ratchetIn evolutionary genetics, Muller's ratchet (named after Hermann Joseph Muller, by analogy with a ratchet effect) is a process which, in the absence of recombination (especially in an asexual population), results in an accumulation of irreversible deleterious mutations. This happens because in the absence of recombination, and assuming reverse mutations are rare, offspring bear at least as much mutational load as their parents.
EpistasisEpistasis is a phenomenon in genetics in which the effect of a gene mutation is dependent on the presence or absence of mutations in one or more other genes, respectively termed modifier genes. In other words, the effect of the mutation is dependent on the genetic background in which it appears. Epistatic mutations therefore have different effects on their own than when they occur together. Originally, the term epistasis specifically meant that the effect of a gene variant is masked by that of a different gene.
Gestalt psychologyGestalt psychology, gestaltism, or configurationism is a school of psychology that emerged in the early twentieth century in Austria and Germany as a theory of perception that was a rejection of basic principles of Wilhelm Wundt's and Edward Titchener's elementalist and structuralist psychology. As used in Gestalt psychology, the German word Gestalt (gəˈʃtaelt,-'Stɑːlt,-ˈʃtɔːlt,-ˈstɑːlt,-ˈstɔːlt ɡəˈʃtalt; meaning "form") is interpreted as "pattern" or "configuration".
Sensory thresholdIn psychophysics, sensory threshold is the weakest stimulus that an organism can sense. Unless otherwise indicated, it is usually defined as the weakest stimulus that can be detected half the time, for example, as indicated by a point on a probability curve. Methods have been developed to measure thresholds in any of the senses. Several different sensory thresholds have been defined; Absolute threshold: the lowest level at which a stimulus can be detected. Recognition threshold: the level at which a stimulus can not only be detected but also recognized.
Inbreeding depressionInbreeding depression is the reduced biological fitness which has the potential to result from inbreeding (the breeding of related individuals). Biological fitness refers to an organism's ability to survive and perpetuate its genetic material. Inbreeding depression is often the result of a population bottleneck. In general, the higher the genetic variation or gene pool within a breeding population, the less likely it is to suffer from inbreeding depression, though inbreeding and outbreeding depression can simultaneously occur.
Gestalt therapyGestalt therapy is a form of psychotherapy that emphasizes personal responsibility and focuses on the individual's experience in the present moment, the therapist–client relationship, the environmental and social contexts of a person's life, and the self-regulating adjustments people make as a result of their overall situation. It was developed by Fritz Perls, Laura Perls and Paul Goodman in the 1940s and 1950s, and was first described in the 1951 book Gestalt Therapy.
Absolute thresholdIn neuroscience and psychophysics, an absolute threshold was originally defined as the lowest level of a stimulus – light, sound, touch, etc. – that an organism could detect. Under the influence of signal detection theory, absolute threshold has been redefined as the level at which a stimulus will be detected a specified percentage (often 50%) of the time. The absolute threshold can be influenced by several different factors, such as the subject's motivations and expectations, cognitive processes, and whether the subject is adapted to the stimulus.
Peer supportPeer support occurs when people provide knowledge, experience, emotional, social or practical help to each other. It commonly refers to an initiative consisting of trained supporters (although it can be provided by peers without training), and can take a number of forms such as peer mentoring, reflective listening (reflecting content and/or feelings), or counseling. Peer support is also used to refer to initiatives where colleagues, members of self-help organizations and others meet, in person or online, as equals to give each other connection and support on a reciprocal basis.
Vernier, SwitzerlandVernier (vɛʁnje) is a municipality in the Canton of Geneva, Switzerland. It is divided into different sections: Vernier Village, Le Lignon, Aïre, Les Avanchets, Cointrin and Châtelaine. The name "Vernier" has its roots in the Latin language. It is believed to be derived from the Latin word "verna," meaning "slave" or "servant." Over time, the name evolved to "Vernier," possibly referring to a person or family associated with servitude or service.
Social supportSocial support is the perception and actuality that one is cared for, has assistance available from other people, and most popularly, that one is part of a supportive social network. These supportive resources can be emotional (e.g., nurturance), informational (e.g., advice), or companionship (e.g., sense of belonging); tangible (e.g., financial assistance) or intangible (e.g., personal advice). Social support can be measured as the perception that one has assistance available, the actual received assistance, or the degree to which a person is integrated in a social network.
Euclid's ElementsEuclid's Elements (Στοιχεῖα Stoikheîa) is a mathematical treatise consisting of 13 books attributed to the ancient Greek mathematician Euclid in Alexandria, Ptolemaic Egypt 300 BC. It is a collection of definitions, postulates, propositions (theorems and constructions), and mathematical proofs of the propositions. The books cover plane and solid Euclidean geometry, elementary number theory, and incommensurable lines. Elements is the oldest extant large-scale deductive treatment of mathematics.
SatignySatigny is a municipality of the Canton of Geneva, Switzerland. It is the largest municipality of the canton by land area and the largest wine-producing municipality of the country. Its territory contains the majority of the Mandement area, a designated heritage site of national importance shared with the neighbouring municipalities of Russin and Dardagny. Satigny is first mentioned in 91 as villam Satiniatis, though this comes from a 12th Century copy of the earlier document.
Synthetic-aperture radarSynthetic-aperture radar (SAR) is a form of radar that is used to create two-dimensional images or three-dimensional reconstructions of objects, such as landscapes. SAR uses the motion of the radar antenna over a target region to provide finer spatial resolution than conventional stationary beam-scanning radars. SAR is typically mounted on a moving platform, such as an aircraft or spacecraft, and has its origins in an advanced form of side looking airborne radar (SLAR).
Lambert azimuthal equal-area projectionThe Lambert azimuthal equal-area projection is a particular mapping from a sphere to a disk. It accurately represents area in all regions of the sphere, but it does not accurately represent angles. It is named for the Swiss mathematician Johann Heinrich Lambert, who announced it in 1772. "Zenithal" being synonymous with "azimuthal", the projection is also known as the Lambert zenithal equal-area projection. The Lambert azimuthal projection is used as a map projection in cartography.
Stratocumulus cloudA stratocumulus cloud, occasionally called a cumulostratus, belongs to a genus-type of clouds characterized by large dark, rounded masses, usually in groups, lines, or waves, the individual elements being larger than those in altocumulus, and the whole being at a lower height, usually below . Weak convective currents create shallow cloud layers because of drier, stable air above preventing continued vertical development. Historically, in English, this type of cloud has been referred to as a twain cloud for being a combination of two types of clouds.
GenevaGeneva (dʒəˈniːvə ; Genève ʒənɛv) is the second-most populous city in Switzerland (after Zürich) and the most populous city of Romandy, the French-speaking part of Switzerland. Situated in the south west of the country, where the Rhône exits Lake Geneva, it is the capital of the Republic and Canton of Geneva, and a center for international diplomacy. The city of Geneva (ville de Genève) had a population of 203,951 in 2020 (Jan. estimate) within its small municipal territory of , but the Canton of Geneva (the city and its closest Swiss suburbs and exurbs) had a population of 504,128 (Jan.
RadarRadar is a radiolocation system that uses radio waves to determine the distance (ranging), angle (azimuth), and radial velocity of objects relative to the site. It is used to detect and track aircraft, ships, spacecraft, guided missiles, and motor vehicles, and map weather formations, and terrain. A radar system consists of a transmitter producing electromagnetic waves in the radio or microwaves domain, a transmitting antenna, a receiving antenna (often the same antenna is used for transmitting and receiving) and a receiver and processor to determine properties of the objects.
