Publication

System for control of autonomic dysreflexia

2025

Abstract

The invention provides a neuromodulation/neurostimulation system (10) for stimulating sympathetic circuitry responsible for blood pressure control in a mammal with autonomic dysreflexia, said system (10) comprising: at least one control unit (12) configured and arranged to provide stimulation data, and at least one stimulation unit (14), operatively connected to the at least one control unit (12), said at least one stimulation unit (14) being configured and arranged to provide electrical stimulation to the spinal cord of said mammal, preferably at thoracic level, more preferably around spinal cord level t10-t12. the at least one stimulation unit (14) includes an implantable lead (18). the neuromodulation/neurostimulation system is configured and arranged to provide neuromodulation to said mammal to activate the sympathetic circuitry responsible for blood pressure control that mitigates autonomic dysreflexia.

Official source

https://infoscience.epfl.ch/entities/publication/866c4a53-5e08-4c43-917f-a69b43c8142a

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2025

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/866c4a53-5e08-4c43-917f-a69b43c8142a

About this result

Related concepts (32)

Neurostimulation

Neurostimulation is the purposeful modulation of the nervous system's activity using invasive (e.g. microelectrodes) or non-invasive means (e.g. transcranial magnetic stimulation or transcranial electric stimulation, tES, such as tDCS or transcranial alternating current stimulation, tACS). Neurostimulation usually refers to the electromagnetic approaches to neuromodulation.

Spinal cord injury

A spinal cord injury (SCI) is damage to the spinal cord that causes temporary or permanent changes in its function. Symptoms may include loss of muscle function, sensation, or autonomic function in the parts of the body served by the spinal cord below the level of the injury. Injury can occur at any level of the spinal cord and can be complete, with a total loss of sensation and muscle function at lower sacral segments, or incomplete, meaning some nervous signals are able to travel past the injured area of the cord up to the Sacral S4-5 spinal cord segments.

Spinal cord

The spinal cord is a long, thin, tubular structure made up of nervous tissue, which extends from the medulla oblongata in the brainstem to the lumbar region of the vertebral column (backbone). The backbone encloses the central canal of the spinal cord, which contains cerebrospinal fluid. The brain and spinal cord together make up the central nervous system (CNS). In humans, the spinal cord begins at the occipital bone, passing through the foramen magnum and then enters the spinal canal at the beginning of the cervical vertebrae.