Publication

Microstructural cortical maturation underlies longitudinal BOLD signal variability of emerging resting-state networks in preterm infants

2024

Abstract

Motivation: BOLD signal variability (BOLD-SD) has emerged as a measure for assessing brain function, but little is known regarding its biological significance. Goal(s): Demonstrate that cortical BOLD-SD modifications are accompanied by structural intracortical maturational changes. Elucidate brain networks undergoing the most important maturational changes during early development. Approach: Longitudinal brain MRI acquisition in preterm infants at 33 and 40 weeks’ gestational age. Assessment of cortical BOLD-SD and NODDI indices longitudinal modifications per brain network. Results: A significant longitudinal cortical BOLD-SD increase is observed in primary sensory networks and Default-Mode-Network, accompanied by a decreased NDI (neurite-density-index) and/or increased ODI (orientation-dispersion-index), reflecting concomitant structural intracortical maturation. Impact: During early brain development, the BOLD signal variability increase in resting-state networks was associated to underlying structural intracortical maturational changes and thus it can be considered as a marker of cortical maturation.

Official source

https://infoscience.epfl.ch/entities/publication/85a82f19-1ff6-4feb-b3cf-09a2ec8c38c9

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2024

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/85a82f19-1ff6-4feb-b3cf-09a2ec8c38c9

About this result

Related concepts (31)

Large-scale brain network

Large-scale brain networks (also known as intrinsic brain networks) are collections of widespread brain regions showing functional connectivity by statistical analysis of the fMRI BOLD signal or other recording methods such as EEG, PET and MEG. An emerging paradigm in neuroscience is that cognitive tasks are performed not by individual brain regions working in isolation but by networks consisting of several discrete brain regions that are said to be "functionally connected".

Human brain

The human brain is the central organ of the human nervous system, and with the spinal cord makes up the central nervous system. The brain consists of the cerebrum, the brainstem and the cerebellum. It controls most of the activities of the body, processing, integrating, and coordinating the information it receives from the sense organs, and making decisions as to the instructions sent to the rest of the body. The brain is contained in, and protected by, the skull bones of the head.

Brain

A brain is an organ that serves as the center of the nervous system in all vertebrate and most invertebrate animals. It is located in the head, usually close to the sensory organs for senses such as vision. It is the most complex organ in a vertebrate's body. In a human, the cerebral cortex contains approximately 14–16 billion neurons, and the estimated number of neurons in the cerebellum is 55–70 billion. Each neuron is connected by synapses to several thousand other neurons.

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Microstructural cortical maturation underlies longitudinal BOLD signal variability of emerging resting-state networks in preterm infants

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