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Result 1: Lake microbial communities were successfully grown and maintained inside chemostats Result 2: Seeded chemostats exhibit similar inactivation rates-Fast inactivation against HAdV2 and slow against CVB5 METHODS We combined engineering and biological approaches to assess viral inactivation by lake microbial communities against two enteric viruses: Human Adenovirus 2 (HAdV2) and Coxsackievirus B5 (CVB5).