Application of imaging mass spectrometry approaches to facilitate metal-based anticancer drug research

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Cyclic peptides are fascinating molecules abundantly found in nature and exploited as molecular format for drug development as well as other applications, ranging from research tools to food additives. Advances in peptide technologies made over many years ...

This article explores the escalating impact of natural disasters, particularly droughts, in the Southern African Development Community (SADC), with a specific focus on Eswatini. Over the last century, approximately 63 million people in SADC countries have ...

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The present invention relates to 6-diazo-5-oxo-L-norleucine prodrugs having reduced toxicity and increased tumor specificity and to their therapeutic use for treating cancer. ...

The reversible formation of hydrogen bonds is a ubiquitous mechanism for controlling molecular assembly in biological systems. However, achieving predictable reversibility in artificial two-dimensional (2D) materials remains a significant challenge. Here, ...

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Bebras tasks are considered to develop Computational Thinking (CT) and are currently used for this purpose in many studies. However, the relationship between Bebras tasks and CT is recent and, given the scarcity of validated instruments for assessing CT th ...

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Differentiable rendering (DR) is an emerging field that facilitates the calculation and propagation of gradients of 3D objects through images. In contrast to deep neural networks (DNNs), which generally lack the understanding of 3D objects that form the im ...

Aims: Sirtuin 7 (SIRT7) plays an important role in tumor development, and has been characterized as a potent regulator of cellular stress. However, the effect of SIRT7 on sorafenib acquired resistance remains unclear and a possible anti-tumor mechanism bey ...

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OBJECTIVE: Malignant pleural mesothelioma (MPM) is a rare disease that has a poor response to conventional therapy. Hyperthermic intrathoracic chemotherapy (HITOC), a treatment combining fever-range hyperthermia with intrapleural cisplatin chemotherapy, ha ...

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Studies on urban environmental quality are evolving emphasizing the need for policy response concerning the enactment of environmental regulations to attain sustainable development goals (SDGs), mainly target 13. Over the years, the concerns to improve urb ...

Application of imaging mass spectrometry approaches to facilitate metal-based anticancer drug research

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Cyclic Peptides for Drug Development

Geospatial Tools and Remote Sensing Strategies for Timely Humanitarian Response: A Case Study on Drought Monitoring in Eswatini

Cytokine-armed dendritic cell progenitors for antigen-agnostic cancer immunotherapy

6-diazo-5-oxo-l-norleucine prodrugs

Rational Design of 2D Supramolecular Networks Switchable by External Electric Fields

The role of LRRK2 in lung adenocarcinoma

A Bebras Computational Thinking (ABC-Thinking) program for primary school: Evaluation using the competent computational thinking test

Fungal mycelia: From innovative materials to promising products: Insights and challenges

Inverse Rendering for PET Image Reconstruction

Inhibition of SIRT7 overcomes sorafenib acquired resistance by suppressing ERK1/2 phosphorylation via the DDX3X-mediated NLRP3 inflammasome in hepatocellular carcinoma

Light electric vehicle sharing systems: Functional design of a comprehensive decision making solution

Impact of substrate clogging on vertical connectivity

Swiss dams: Overview of historical development

Mechanism of KRAS-driven T cell infiltration in colorectal cancer

Identification of human milk oligosaccharide positional isomers by combining IMS-CID-IMS and cryogenic IR spectroscopy

Hyperthermic intrathoracic chemotherapy to control malignant pleural mesothelioma

Tumor dormancy: EMT beyond invasion and metastasis

Deep learning-based solid component measuring enabled interpretable prediction of tumor invasiveness for lung adenocarcinoma

The predictive capacity of in vitro preclinical models to evaluate drugs for the treatment of retinoblastoma

Determinants of urban environmental quality in Morocco: The roles of energy consumption, urbanization, manufacturing, and financial development in SDG 13