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Implantable Neuro-Modulation Devices and Technology

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X-Band Aom On Chip

Tobias Kippenberg, Junqiu Liu, Anat Siddharth, Terence Albert Emile Blésin

Silicon Nitride integrated photonic circuits have drawn much attention owing to its ultra-low loss and large Kerr nonlinearity. However, the lack of Pockels effect makes it difficult to be modulated clectro-optically, which posts a major challenge for the ...

IEEE2021

Methods to Enhance Nuclear Magnetic Resonance Sensitivity at High Magnetic Field

Claudia Christina Zanella

MR is a well-established technique routinely used in preclinical and clinical studies. This thesis focussed on the improvement of sensitivity of different methods in MR. Hyperpolarized 129Xe gas is used for studying pulmonary disease or cerebral perfusion ...

EPFL2021

Decentralized Gan Training Through Diffusion Learning

Ali H. Sayed, Noé Stauffer

Most available studies on distributed GAN architectures focus on implementations with a fusion center. In this work, we propose a fully decentralized scheme by employing a diffusion strategy to train a network of GANs. We interpret the training procedure a ...

IEEE2022

Simulation and experimental study of proton bunch self-modulation in plasma with linear density gradients

Ambrogio Fasoli, Sun Hee Kim, Ivo Furno, Patrick Blanchard, Yanis Andrebe, Riccardo Agnello, Alban Sublet, Falk Hans Braunmüller, Christine Stollberg

We present numerical simulations and experimental results of the self-modulation of a long proton bunch in a plasma with linear density gradients along the beam path. Simulation results agree with the experimental results reported [F. Braunmller, T. Nechae ...

2021

Adversarial training with informed data selection

Pascal Frossard, Javier Alejandro Maroto Morales

With the increasing amount of available data and advances in computing capabilities, deep neural networks (DNNs) have been successfully employed to solve challenging tasks in various areas, including healthcare, climate, and finance. Nevertheless, state-of ...

IEEE2022

High-Speed ADC Design and Optimization for Wireline Links

Ayça Akkaya

The ever-growing global internet traffic has increased demand for higher speed data transmission. As the bandwidth requirements of wireline links increase, extensive digital equalization techniques are required to compensate for the high-frequency channel ...

EPFL2021

Gigahertz free-space electro-optic modulators based on Mie resonances

Ileana-Cristina Benea-Chelmus

Electro-optic modulators are essential for sensing, metrology and telecommunications. Most target fiber applications. Instead, metasurface-based architectures that modulate free-space light at gigahertz (GHz) speeds can boost flat optics technology by micr ...

Nature Portfolio2022

Ultrafast Photon-Induced Tunneling Microscopy

Klaus Kern

Unification of the techniques of ultrafast science and scanning tunneling microscopy (STM) has the potential of tracking electronic motion in molecules simultaneously in real space and real time. Laser pulses can couple to an STM junction either in the wea ...

AMER CHEMICAL SOC2021

Polysaccharide Layer-by-Layer Coating for Polyimide-Based Neural Interfaces

Silvestro Micera

Implantable flexible neural interfaces (IfNIs) are capable of directly modulating signals of the central and peripheral nervous system by stimulating or recording the action potential. Despite outstanding results in acute experiments on animals and humans, ...

MDPI2022

Time-Varying Components for Enhancing Wireless Transfer of Power and Information

Romain Christophe Rémy Fleury, Mohammad Sajjad Mirmoosa

Temporal modulation of components of electromagnetic systems provides an exceptional opportunity to engineer the response of those systems in a desired fashion, both in the time and frequency domains. For engineering time-modulated systems, one needs to th ...

American Physical Society (APS)2021

Altered heart cytokine profile and action potential modulation in cardiomyocytes from Mas-deficient mice

Analina Raquel Hausin

The renin-angiotensin system (RAS) is a key hormonal system. In recent years, the functional analysis of the novel axis of the RAS (ACE2/Ang-(1-7)/Mas receptor) revealed that its activation can become pro-tective against several pathologies, including card ...

ACADEMIC PRESS INC ELSEVIER SCIENCE2022

Soft materials and technologies for neural interfaces

Michael Shur

Implantable neural interfaces are an emerging concept which is revolutionizing various domains of medicine and rehabilitation. However, the long-term efficiency and reliability of these devices is often limited, mainly attributed to the fundamental differe ...

EPFL2021

Thermally reconfigurable metalens

Giulia Tagliabue, Anna Archetti, Fateme Kiani Shahvandi, Theodoros Tsoulos, Nathanaël Restori, Ren-Jie Lin

Reconfigurable metalenses are compact optical components composed by arrays of meta-atoms that offer unique opportunities for advanced optical systems, from microscopy to augmented reality platforms. Although poorly explored in the context of reconfigurabl ...

WALTER DE GRUYTER GMBH2022

Comprehensive Spectral Analysis of PWM Waveforms With Compensated DC link Oscillations

Drazen Dujic, Stefan Milovanovic

In the available literature, including reference books on the topic, the spectral analysis of voltage waveforms obtained through the use of pulse-width modulation relies on the assumption of an ideally flat voltage across the DC link of a considered switch ...

2020

Modulation of Subcellular Redox Homeostasis with Trialkylphosphines

Jade Noémie Nam Nguyen

Redox homeostasis is essential for cell function and its disruption is associated with multiple pathologies. Redox balance is largely regulated by the relative concentrations of reduced (GSH) and oxidized (GSSG) glutathione. In eukaryotic cells, this ratio ...

SWISS CHEMICAL SOC2022

Demonstration of Tunable Optical Aggregation of QPSK to 16-QAM Over Optically Generated Nyquist Pulse Trains Using Nonlinear Wave Mixing and a Kerr Frequency Comb

Tobias Kippenberg, Maxim Karpov, Martin Hubert Peter Pfeiffer, Arne Kordts, Fatemeh Alishahi

A tunable and reconfigurable optical aggregation system is experimentally demonstrated. Optical Nyquist pulses are generated on multiple channels using a microresonator-based Kerr optical frequency comb and insertion of uniform lines by an intensity modula ...

IEEE Institute of Electrical and Electronics Engineers2020

Efficient Preparation of Cyclic Quantum States

Giovanni De Micheli, Fereshte Mozafari Ghoraba

Universal quantum algorithms that prepare arbitrary n-qubit quantum states require O(2n) gate complexity. The complexity can be reduced by considering specific families of quantum states depending on the task at hand. In particular, multipartite quantum st ...

IEEE2022

A semantic-driven tradespace framework to accelerate aircraft manufacturing system design

Dimitrios Kyritsis, Jinzhi Lu, Xiaochen Zheng

During the design phase of an aircraft manufacturing system, different industrial scenarios need to be evaluated according to key performance indicators to achieve the optimal system performance. It is a highly complex process involving multidisciplinary s ...

SPRINGER2022

Nonlinear effects in synthetic frequency dimension created by electro-optical modulation of a ring resonator

Tobias Kippenberg, Alexey Tikan, Aleksandr Tusnin

We numerically investigate the nonlinear dynamics of an optical resonator with electro-optical modulation. In this system we discover chimera states and their transition into new stable states with increasing modulation amplitude. Bifurcation analysis reve ...

IEEE2020

GABA-mediated tonic inhibition differentially modulates gain in functional subtypes of cortical interneurons

Sean Lewis Hill, Christian Andreas Rössert, Bas-Jan Zandt

The binding of GABA (gamma-aminobutyric acid) to extrasynaptic GABA(A) receptors generates tonic inhibition that acts as a powerful modulator of cortical network activity. Despite GABA being present throughout the extracellular space of the brain, previous ...

National Academy of Sciences2020