Publication

ID: 338536 Computational Pipeline for Modeling Ultrasound Propagation and Electrophysiological Impacts for Non-invasive Peripheral Nervous System Stimulation

2024

Abstract

Focused ultrasound is gaining attention as an innovative non-invasive and potentially cell-type selective neuromodulation technology with high spatial resolution. However, the underlying biophysical mechanisms of ultrasound neuromodulation (UNMOD) are not well understood. The UNMOD project aims to establish the first experimentally validated computational pipeline of ultrasound propagation and axonal response for peripheral nerve stimulation, and to share it through the o2S2PARC-platform for open, FAIR and collaborative computational neurosciences. The model shall integrate a broad set of candidate mechanisms of ultrasound-electrophysiology coupling.

Official source

https://infoscience.epfl.ch/entities/publication/83cca1dc-2428-4b29-9e09-9e4995912e40

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2024

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/83cca1dc-2428-4b29-9e09-9e4995912e40

About this result

Related concepts (31)

Axon

An axon (from Greek ἄξων áxōn, axis), or nerve fiber (or nerve fibre: see spelling differences), is a long, slender projection of a nerve cell, or neuron, in vertebrates, that typically conducts electrical impulses known as action potentials away from the nerve cell body. The function of the axon is to transmit information to different neurons, muscles, and glands.

Axon guidance

Axon guidance (also called axon pathfinding) is a subfield of neural development concerning the process by which neurons send out axons to reach their correct targets. Axons often follow very precise paths in the nervous system, and how they manage to find their way so accurately is an area of ongoing research. Axon growth takes place from a region called the growth cone and reaching the axon target is accomplished with relatively few guidance molecules. Growth cone receptors respond to the guidance cues.

Computational neuroscience

Computational neuroscience (also known as theoretical neuroscience or mathematical neuroscience) is a branch of neuroscience which employs mathematical models, computer simulations, theoretical analysis and abstractions of the brain to understand the principles that govern the development, structure, physiology and cognitive abilities of the nervous system. Computational neuroscience employs computational simulations to validate and solve mathematical models, and so can be seen as a sub-field of theoretical neuroscience; however, the two fields are often synonymous.

Related publications (1)

ID: 338536 Computational Pipeline for Modeling Ultrasound Propagation and Electrophysiological Impacts for Non-invasive Peripheral Nervous System Stimulation

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