Publication

Stable ß-Turns of Tripeptides in Water through Cation-π Interactions

Karl Gademann
2008
Journal Articles

Abstract

Taking a a turn. Short tripeptides that form stable ß turns in water are remarkably stable against chemical and thermal degradation. Terminal cation-π interactions lead to stabilization of these turns that are formed independently of sequence.

Official source

https://infoscience.epfl.ch/entities/publication/83c7644b-41c6-42d4-ba08-9de21e500cf4

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Karl Gademann
2008
Journal Articles

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/83c7644b-41c6-42d4-ba08-9de21e500cf4

About this result

Related concepts (6)

Cation–π interaction

Cation–π interaction is a noncovalent molecular interaction between the face of an electron-rich π system (e.g. benzene, ethylene, acetylene) and an adjacent cation (e.g. Li+, Na+). This interaction is an example of noncovalent bonding between a monopole (cation) and a quadrupole (π system). Bonding energies are significant, with solution-phase values falling within the same order of magnitude as hydrogen bonds and salt bridges.

Pi-interaction

In chemistry, π-effects or π-interactions are a type of non-covalent interaction that involves π systems. Just like in an electrostatic interaction where a region of negative charge interacts with a positive charge, the electron-rich π system can interact with a metal (cationic or neutral), an anion, another molecule and even another π system. Non-covalent interactions involving π systems are pivotal to biological events such as protein-ligand recognition.

Stacking (chemistry)

In chemistry, pi stacking (also called π–π stacking) refers to the presumptive attractive, noncovalent pi interactions (orbital overlap) between the pi bonds of aromatic rings. However this is a misleading description of the phenomena since direct stacking of aromatic rings (the "sandwich interaction") is electrostatically repulsive.

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