Publication

Effect of Hypoxia and Hyperoxia on Baroreflex Sensitivity at Sea Level and Altitude

Jean-Marc Vesin
2016
Conference Papers

Abstract

This paper is part of a series titled “AltitudeOmics” that together represent a group of studies that explore the basic mechanisms controlling human acclimatization to hypoxia. This study aims at analyzing the baroreflex sensitivity (BRS) at sea level, in acute and chronic hypoxia and test whether hyperoxia reverts the hypoxic effects. Twenty-one young, healthy subjects underwent experimental trials near sea level, and two times at high altitude. BRS was calculated using the sequence method, spectral method, transfer function and the standard deviation method. Results showed a decrease in BRS with hypoxic exposures. Hyperoxia reverted the hypoxic effects in acute hypoxia only. In chronic hypoxia, BRS reset to lower values but behaved comparably to normoxia.

Official source

https://infoscience.epfl.ch/entities/publication/832d16ee-4136-47b4-a19c-7fead912a6f1

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Jean-Marc Vesin
2016
Conference Papers

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/832d16ee-4136-47b4-a19c-7fead912a6f1

About this result

Related concepts (32)

Hypoxia (medical)

Hypoxia is a condition in which the body or a region of the body is deprived of adequate oxygen supply at the tissue level. Hypoxia may be classified as either generalized, affecting the whole body, or local, affecting a region of the body. Although hypoxia is often a pathological condition, variations in arterial oxygen concentrations can be part of the normal physiology, for example, during strenuous physical exercise.

Hypoxemia

Hypoxemia is an abnormally low level of oxygen in the blood. More specifically, it is oxygen deficiency in arterial blood. Hypoxemia has many causes, and often causes hypoxia as the blood is not supplying enough oxygen to the tissues of the body. Hypoxemia refers to the low level of oxygen in blood, and the more general term hypoxia is an abnormally low oxygen content in any tissue or organ, or the body as a whole. Hypoxemia can cause hypoxia (hypoxemic hypoxia), but hypoxia can also occur via other mechanisms, such as anemia.

Cerebral hypoxia

Cerebral hypoxia is a form of hypoxia (reduced supply of oxygen), specifically involving the brain; when the brain is completely deprived of oxygen, it is called cerebral anoxia. There are four categories of cerebral hypoxia; they are, in order of increasing severity: diffuse cerebral hypoxia (DCH), focal cerebral ischemia, cerebral infarction, and global cerebral ischemia. Prolonged hypoxia induces neuronal cell death via apoptosis, resulting in a hypoxic brain injury.