Randomized experimentIn science, randomized experiments are the experiments that allow the greatest reliability and validity of statistical estimates of treatment effects. Randomization-based inference is especially important in experimental design and in survey sampling. In the statistical theory of design of experiments, randomization involves randomly allocating the experimental units across the treatment groups. For example, if an experiment compares a new drug against a standard drug, then the patients should be allocated to either the new drug or to the standard drug control using randomization.
Longitudinal studyA longitudinal study (or longitudinal survey, or panel study) is a research design that involves repeated observations of the same variables (e.g., people) over long periods of time (i.e., uses longitudinal data). It is often a type of observational study, although it can also be structured as longitudinal randomized experiment.
Placebo-controlled studyPlacebo-controlled studies are a way of testing a medical therapy in which, in addition to a group of subjects that receives the treatment to be evaluated, a separate control group receives a sham "placebo" treatment which is specifically designed to have no real effect. Placebos are most commonly used in blinded trials, where subjects do not know whether they are receiving real or placebo treatment. Often, there is also a further "natural history" group that does not receive any treatment at all.
Lower respiratory tract infectionLower respiratory tract infection (LRTI) is a term often used as a synonym for pneumonia but can also be applied to other types of infection including lung abscess and acute bronchitis. Symptoms include shortness of breath, weakness, fever, coughing and fatigue. A routine chest X-ray is not always necessary for people who have symptoms of a lower respiratory tract infection. Influenza affects both the upper and lower respiratory tracts. Antibiotics are the first line treatment for pneumonia; however, they are neither effective nor indicated for parasitic or viral infections.
Calendar reformCalendar reform or calendrical reform is any significant revision of a calendar system. The term sometimes is used instead for a proposal to switch to a different calendar design. The prime objective of a calendar is to unambiguously identify any day in past, present and future by a specific date in order to record or organize social, religious, commercial or administrative events. Recurring periods that contain multiple days, such as weeks, months, and years, are secondary, convenient features of a calendar.
Zoster vaccineA zoster vaccine is a vaccine that reduces the incidence of herpes zoster (shingles), a disease caused by reactivation of the varicella zoster virus, which is also responsible for chickenpox. Shingles provokes a painful rash with blisters, and can be followed by chronic pain (postherpetic neuralgia), as well as other complications. Older people are more often affected, as are people with weakened immune systems (immunosuppression). Both shingles and postherpetic neuralgia can be prevented by vaccination.
Rubella vaccineRubella vaccine is a vaccine used to prevent rubella. Effectiveness begins about two weeks after a single dose and around 95% of people become immune. Countries with high rates of immunization no longer see cases of rubella or congenital rubella syndrome. When there is a low level of childhood immunization in a population it is possible for rates of congenital rubella to increase as more women make it to child-bearing age without either vaccination or exposure to the disease.
Holocene calendarThe Holocene calendar, also known as the Holocene Era or Human Era (HE), is a year numbering system that adds exactly 10,000 years to the currently dominant (AD/BC or CE/BCE) numbering scheme, placing its first year near the beginning of the Holocene geological epoch and the Neolithic Revolution, when humans shifted from a hunter-gatherer lifestyle to agriculture and fixed settlements. The current year by the Gregorian calendar, AD , is HE in the Holocene calendar.
Chinese calendarThe traditional Chinese calendar is a lunisolar calendar which identifies years, months, and days according to astronomical phenomena. In China, it is defined by the Chinese national standard GB/T 33661–2017, "Calculation and Promulgation of the Chinese Calendar", issued by the Standardization Administration of China on May 12, 2017. Traditional Chinese calendar also known as these five titles: Nongli Calendar (traditional Chinese: 農曆; simplified Chinese: 农历; pinyin: nónglì; lit.
Babylonian calendarThe Babylonian calendar was a lunisolar calendar with years consisting of 12 lunar months, each beginning when a new crescent moon was first sighted low on the western horizon at sunset, plus an intercalary month inserted as needed by decree. The calendar is based on a Sumerian (Third Dynasty of Ur) predecessor preserved in the Umma calendar of Shulgi (c. 21st century BC). The year begins in spring, and is divided into 12 months. The word for "month" was arḫu (construct state araḫ).
Mathematical modelling of infectious diseasesMathematical models can project how infectious diseases progress to show the likely outcome of an epidemic (including in plants) and help inform public health and plant health interventions. Models use basic assumptions or collected statistics along with mathematics to find parameters for various infectious diseases and use those parameters to calculate the effects of different interventions, like mass vaccination programs. The modelling can help decide which intervention(s) to avoid and which to trial, or can predict future growth patterns, etc.
CoinfectionCoinfection is the simultaneous infection of a host by multiple pathogen species. In virology, coinfection includes simultaneous infection of a single cell by two or more virus particles. An example is the coinfection of liver cells with hepatitis B virus and hepatitis D virus, which can arise incrementally by initial infection followed by superinfection. Global prevalence or incidence of coinfection among humans is unknown, but it is thought to be commonplace, sometimes more common than single infection.
