Publication

Functional differentiation of tbf1 orthologues in fission and budding yeasts

Related publications (28)

Identification of genetic interactors of ypa2 in Schizosaccharomyces pombe

In this study, the fission yeast Schizosaccharomyces pombe was used as a model system to study the cellular signaling that underlies cell cycle progression. Phosphorylation plays an important part in the regulation of this process. Kinases catalyze the tra ...

EPFL2016

Pombe's thirteen - control of fission yeast cell division by the septation initiation network

Viesturs Simanis

The septation initiation network (SIN) regulates aspects of cell growth and division in Schizosaccharomyces pombe and is essential for cytokinesis. Insufficient signalling results in improper assembly of the contractile ring and failure of cytokinesis, gen ...

Company Of Biologists Ltd2015

A formin-nucleated actin aster concentrates cell wall hydrolases for cell fusion in fission yeast

Thierry Laroche, Arne Seitz, Raphaël Groux, Omaya Pierre Dudin

Cell-cell fusion is essential for fertilization. For fusion of walled cells, the cell wall must be degraded at a precise location but maintained in surrounding regions to protect against lysis. In fission yeast cells, the formin Fus1, which nucleates linea ...

Rockefeller University Press2015

An Extended, Boolean Model of the Septation Initiation Network in S-pombe Provides Insights into Its Regulation

Viesturs Simanis, Andrea Krapp, Elena Cano, Anastasia Chasapi, Ioannis Xenarios

Cytokinesis in fission yeast is controlled by the Septation Initiation Network (SIN), a protein kinase signaling network using the spindle pole body as scaffold. In order to describe the qualitative behavior of the system and predict unknown mutant behavio ...

Public Library of Science2015

Molecular Mechanism of Flocculation Self-Recognition in Yeast and Its Role in Mating and Survival

Jens Nielsen, Sandor Kasas, Livan Bladimir Alonso Sarduy

We studied the flocculation mechanism at the molecular level by determining the atomic structures of N-Flo1p and N-Lg-Flo1p in complex with their ligands. We show that they have similar ligand binding mechanisms but distinct carbohydrate specificities and ...

American Society for Microbiology2015

An impedance-based flow microcytometer for single cell morphology discrimination

Philippe Renaud, Ludovica Colella, Marjan Shaker

Cell shape is a fundamental biological feature, providing specific information about physiological or pathological cellular conditions. Most of the state-of-the-art microfluidic cytometers, however, only allow simple cell analysis, including viability stud ...

Royal Soc Chemistry2014

Optimization of the analogue-sensitive Cdc2/Cdk1 mutant by in vivo selection eliminates physiological limitations to its use in cell cycle analysis

Viesturs Simanis

Analogue-sensitive (as) mutants of kinases are widely used to selectively inhibit a single kinase with few off-target effects. The analogue-sensitive mutant cdc2-as of fission yeast (Schizosaccharomyces pombe) is a powerful tool to study the cell cycle, bu ...

Royal Society, The2014

Automated long-term single cell analysis of Schizosaccharomyces pombe on a microfluidic microchemostat array

Jean-Bernard Nobs

How cells grow and divide is a question that was raised more than 100 years ago. Despite years of research and in-depth knowledge of several molecular mechanisms, the complete system that regulates and coordinates both of those activities within Schizosacc ...

EPFL2014