Publication

Protein synthesis - computational modeling and experimental integration

2014
Posters

Abstract

Proteins are among the central elements in every living cell as these ultimately determine how the cell functions. The protein abundances can be regulated at many levels, such as transcription, translation and degradation. As the complexity increases when considering the large number of components involved in the system (eg. mRNA, tRNA, ribosomes and their interactions), some computational study is needed for the analysis of the global regulation related to protein synthesis. Here we will present three projects that demonstrate how mathematical modeling and computational analysis can be used for fundamental analysis and analysis of omics data: • a study of genome-scale properties of Escherichia coli; • an analysis of translatome data of a bacteria, Lactococcus lactis; • an analysis of proteomics data related to drug target identification.

Official source

https://infoscience.epfl.ch/entities/publication/8166dd15-7c23-4911-8db3-5c7e068cd72f

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2014
Posters

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/8166dd15-7c23-4911-8db3-5c7e068cd72f

About this result

Related concepts (32)

Protein

Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific 3D structure that determines its activity.

Cell biology

Cell biology (also cellular biology or cytology) is a branch of biology that studies the structure, function, and behavior of cells. All living organisms are made of cells. A cell is the basic unit of life that is responsible for the living and functioning of organisms. Cell biology is the study of the structural and functional units of cells. Cell biology encompasses both prokaryotic and eukaryotic cells and has many subtopics which may include the study of cell metabolism, cell communication, cell cycle, biochemistry, and cell composition.

Translation

Translation is the communication of the meaning of a source-language text by means of an equivalent target-language text. The English language draws a terminological distinction (which does not exist in every language) between translating (a written text) and interpreting (oral or signed communication between users of different languages); under this distinction, translation can begin only after the appearance of writing within a language community.

Related publications (31)

Protein synthesis - computational modeling and experimental integration

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