Publication

Total Synthesis, Configuration, and Biological Evaluation of Anguinomycin C

Karl Gademann
2007
Journal Articles

Abstract

Immunofluorescence assays indicate that anguinomycin C is a potent inhibitor of protein export from the nucleus. Key features in the total synthesis of this antitumor natural product include a Cr-catalyzed enantioselective hetero-Diels– Alder reaction, a Negishi reaction with stereoinversion, and application of the DIOZ auxiliary.

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Total Synthesis, Configuration, and Biological Evaluation of Anguinomycin C

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