Publication

Positioning and electrophysiological characterization of individual cells and reconstituted membrane systems on microstructured carriers

2004
Patents

Abstract

The invention relates to a measuring device which permits a very simple positioning of cells and vesicles respective of cell membranes on planar carriers. The invention also relates to a corresponding highly efficient method for the positioning and electric characterization of such membranes with a consistently high signal-to-noise ratio. In addition, statements concerning interactions of substances with lipid membranes respective of materials bonded thereon or therein respective of signal transduction mechanisms connected thereto are possible.

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2004
Patents

Abstract

Official source

Related concepts (16)

Cell membrane

The cell membrane (also known as the plasma membrane or cytoplasmic membrane, and historically referred to as the plasmalemma) is a biological membrane that separates and protects the interior of a cell from the outside environment (the extracellular space). The cell membrane consists of a lipid bilayer, made up of two layers of phospholipids with cholesterols (a lipid component) interspersed between them, maintaining appropriate membrane fluidity at various temperatures.

Membrane potential

Membrane potential (also transmembrane potential or membrane voltage) is the difference in electric potential between the interior and the exterior of a biological cell. That is, there is a difference in the energy required for electric charges to move from the internal to exterior cellular environments and vice versa, as long as there is no acquisition of kinetic energy or the production of radiation. The concentration gradients of the charges directly determine this energy requirement.

Semipermeable membrane

Semipermeable membrane is a type of biological or synthetic, polymeric membrane that will allow certain molecules or ions to pass through it by osmosis. The rate of passage depends on the pressure, concentration, and temperature of the molecules or solutes on either side, as well as the permeability of the membrane to each solute. Depending on the membrane and the solute, permeability may depend on solute size, solubility, properties, or chemistry. How the membrane is constructed to be selective in its permeability will determine the rate and the permeability.

Related publications (3)

Positioning and electrophysiological characterization of individual cells and reconstituted membrane systems on microstructured carriers

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