Publication

Synchrotron Spectromicroscopy in Biophysics - Specificity of Metal Uptake by Neurons

Giorgio Margaritondo
1994
Journal Articles

Abstract

Recent instrumentation advances have made it possible to apply experimental synchrotron radiation techniques of materials science to biophysics problems. We present the first results of a systematic photoelectron spectromicroscopy study of the interaction between metals and neurons in vitro. The main result is that aluminum is not uptaken by granule cells-the most common type of neurons-but it is selectively uptaken by cells such as Purkinje neurons and glial cells. On the contrary, granule cells are capable to uptake other metals like Ni and Co.

Official source

https://infoscience.epfl.ch/entities/publication/7f020bb0-e679-44dd-ab47-eab283e7256e

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Giorgio Margaritondo
1994
Journal Articles

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/7f020bb0-e679-44dd-ab47-eab283e7256e

About this result

Related concepts (28)

Glia

Glia, also called glial cells (gliocytes) or neuroglia, are non-neuronal cells in the central nervous system (brain and spinal cord) and the peripheral nervous system that do not produce electrical impulses. The neuroglia make up more than one half the volume of neural tissue in our body. They maintain homeostasis, form myelin in the peripheral nervous system, and provide support and protection for neurons. In the central nervous system, glial cells include oligodendrocytes, astrocytes, ependymal cells and microglia, and in the peripheral nervous system they include Schwann cells and satellite cells.

Radial glial cell

Radial glial cells, or radial glial progenitor cells (RGPs), are bipolar-shaped progenitor cells that are responsible for producing all of the neurons in the cerebral cortex. RGPs also produce certain lineages of glia, including astrocytes and oligodendrocytes. Their cell bodies (somata) reside in the embryonic ventricular zone, which lies next to the developing ventricular system. During development, newborn neurons use radial glia as scaffolds, traveling along the radial glial fibers in order to reach their final destinations.

Glial scar

A glial scar formation (gliosis) is a reactive cellular process involving astrogliosis that occurs after injury to the central nervous system. As with scarring in other organs and tissues, the glial scar is the body's mechanism to protect and begin the healing process in the nervous system. In the context of neurodegeneration, formation of the glial scar has been shown to have both beneficial and detrimental effects.

Related publications (1)

Synchrotron Spectromicroscopy in Biophysics - Specificity of Metal Uptake by Neurons

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High sensitivity quantitative analysis of cobalt uptake in rat cerebellar granule cells with and without excitatory amino acids