Publication

About the "physiological size" of fluorine substituents: comparison of sensorially active compounds with fluorine and methyl substituted analogs

Manfred Schlosser
1996
Journal Articles

Abstract

The taste of four fluoro substituted derivs. is almost indistinguishable from that of the parent compd. 4-(4-hydroxyphenyl)butan-2-one, the main flavor component of raspberries. The same holds for the comparison between the corresponding acetate, another raspberry ingredient, and its 1-fluoro analog. In contrast, Me substituents profoundly alter the organoleptic properties. The prepn. of the fluorinated derivs, involved the three principal options existing for the incorporation of fluorine into org. mol. skeletons: the use of prefabricates (i.e., of fluoroarom. building blocks), the formation of chlorofluorocarbene cycloadducts followed by their solvolytic ring opening and the addn. of fluoride to olefinic double bonds. [on SciFinder (R)]

Official source

https://infoscience.epfl.ch/entities/publication/7de652cf-37be-4707-9ffb-5e06747742cd

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Manfred Schlosser
1996
Journal Articles

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/7de652cf-37be-4707-9ffb-5e06747742cd

About this result

Related concepts (32)

Fluoride

Fluoride (ˈflʊəraɪd,_ˈflɔr-) is an inorganic, monatomic anion of fluorine, with the chemical formula F− (also written [F]−), whose salts are typically white or colorless. Fluoride salts typically have distinctive bitter tastes, and are odorless. Its salts and minerals are important chemical reagents and industrial chemicals, mainly used in the production of hydrogen fluoride for fluorocarbons. Fluoride is classified as a weak base since it only partially associates in solution, but concentrated fluoride is corrosive and can attack the skin.

Fluoride toxicity

Fluoride toxicity is a condition in which there are elevated levels of the fluoride ion in the body. Although fluoride is safe for dental health at low concentrations, sustained consumption of large amounts of soluble fluoride salts is dangerous. Referring to a common salt of fluoride, sodium fluoride (NaF), the lethal dose for most adult humans is estimated at 5 to 10 g (which is equivalent to 32 to 64 mg elemental fluoride/kg body weight). Ingestion of fluoride can produce gastrointestinal discomfort at doses at least 15 to 20 times lower (0.

Fluoride therapy

Fluoride therapy is the use of fluoride for medical purposes. Fluoride supplements are recommended to prevent tooth decay in children older than six months in areas where the drinking water is low in fluoride. It is typically used as a liquid, pill, or paste by mouth. Fluoride has also been used to treat a number of bone diseases. Relatively high ingestion of fluoride by babies and children may result in white marks on the teeth known as fluorosis.