The population genetics of crypsis in vertebrates: recent insights from mice, hares, and lizards

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Motivation Protein language models are enabling advances in elucidating the sequence-to-function mapping, and have important applications in protein design. Models based on multiple sequence alignments efficiently capture the evolutionary information in ho ...

Background: Reproductive isolation can result from adaptive processes (e.g., ecological speciation and mutation-order speciation) or stochastic processes such as "system drift" model. Ecological speciation predicts barriers to gene flow between populations ...

Viral metagenomics is a useful tool for detecting multiple human viruses in urban sewage. However, more refined protocols are required for its effective use in disease surveillance. In this study, we investigated the performance of three different preampli ...

High-throughput transcriptomics is of increasing fundamental biological and clinical interest. The generation of molecular data from large collections of samples, such as biobanks and drug libraries, is boosting the development of new biomarkers and treatm ...

Climate changes influence lake hydrodynamics and radiation levels and thus may affect the fate and transport of waterborne pathogens in lakes. This study examines the impact of climate change on the fate, transport, and associated risks of four waterborne ...

Patterns in nature arise from processes interacting across a continuum of spatial scales, where new relationships emerge at each level of investigation. These patterns are nested features encompassing fine-scale local patterns, such as topography and geolo ...

Gruber et al. (2022) offered a framework how to explain "Physical time within human time", solving the 'two times problem: Here, I am asking whether such a problem exists at all. To question the question, I will appeal to neurobiological, evolutionary, and ...

Cis-genetic effects are key determinants of transcriptional divergence in discrete tissues and cell types. However, how cis- and trans-effects act across continuous trajectories of cellular differentiation in vivo is poorly understood. Here, we quantify al ...

Aims. We derived galaxy colour selections from Euclid and ground-based photometry, aiming to accurately define background galaxy samples in cluster weak-lensing analyses. These selections have been implemented in the Euclid data analysis pipelines for gala ...

Long-term consumption of lipid-rich foods can contribute to common metabolic diseases and systemic low-grade inflammation. However, dietary responses and the development of non-communicable diseases are shaped by genetic factors and gene-by-environment int ...

Owing to stochastic fluctuations arising from finite population size, known as genetic drift, the ability of a population to explore a rugged fitness landscape depends on its size. In the weak mutation regime, while the mean steady-state fitness increases ...

The arms race between viruses and their hosts shaped the evolutionary history and the genome composition of both parties. Restriction factors are the first-line antiviral effectors encoded by the host genomes and are often conserved through evolution to pr ...

This article explores how the logic underlying modal practices tends to modulate the population’s responsiveness to improvements in global transport supply. Based on a quantitative survey conducted in 2018–2019 among the working population of the cantons o ...

Characterizing the genetic structure of large cohorts has become increasingly important as genetic studies extend to massive, increasingly diverse biobanks. Popular methods decompose individual genomes into fractional cluster assignments with each cluster ...

Benchmarking of scATAC-seq protocols demonstrates the effects of data quality on downstream analyses. ...

Mutations to gene regulatory networks can be maladaptive or a source of evolutionary novelty. Epistasis con-founds our understanding of how mutations affect the expression patterns of gene regulatory networks, a chal-lenge exacerbated by the dependence of ...

The present invention relates generally to the field of nucleic acid sequencing and provides oligonucleotide molecules and barcodes contained therein. These oligonucleotide molecules and barcodes molecules are useful in sequencing to identify and resolve e ...

The resilience of the mitochondrial genome (mtDNA) to a high mutational pressure depends, in part, on negative purifying selection in the germline. A paradigm in the field has been that such selection, at least in part, takes place in primordial germ cells ...

An artificial floods program has been implemented on the Sarine residual flow reach, downstream of the Rossens dam. Two artificial floods were released in 2016 (coupled with sediment augmentation) and in 2020. A natural flood occurred in 2021. The indicato ...

The terminology of neurological disorders encompasses a range of serious illnesses (e.g., epilepsy, Alzheimer's disease) leading to morbidity, disability, and stigma. Epilepsy alone affects over 50 million people worldwide, and these figures are rising as ...

The population genetics of crypsis in vertebrates: recent insights from mice, hares, and lizards

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ProtMamba: a homology-aware but alignment-free protein state space model

Reproductive isolation arises during laboratory adaptation to a novel hot environment

Comparison of Three Viral Nucleic Acid Preamplification Pipelines for Sewage Viral Metagenomics

Multi-well plate lid for single-step pooling of 96 samples for high-throughput barcode-based sequencing

Waterborne Virus Transport and Risk Assessment in Lake Geneva Under Climate Change

At what spatial scale does natural selection operate? Using multiscale frameworks to calibrate the effects of environmental factors across landscape continuums

The Two Times Problem: Where Is the Problem?

The dynamic genetic determinants of increased transcriptional divergence in spermatids

Euclid preparation XXXVII. Galaxy colour selections with Euclid and ground photometry for cluster weak-lensing analyses

Identifying genetic and dietary modulators of metabolic disorders using systems genetics

Impact of population size on early adaptation in rugged fitness landscapes

PSGL-1 is an evolutionarily conserved antiviral restriction factor

Analysing the potential for modal shiftbased on the logic of modal choice

Neural ADMIXTURE for rapid genomic clustering

Systematic benchmarking of single-cell ATAC-sequencing protocols

Environment-dependent epistasis increases phenotypic diversity in gene regulatory networks

Optimised set of oligonucleotides for bulk rna barcoding and sequencing

Reanalysis of mtDNA mutations of human primordial germ cells (PGCs) reveals NUMT contamination and suggests that selection in PGCs may be positive

Effects of water releases and sediment supply on a residual flow reach

Real-time Personalized Monitoring of Neurological Disorders on Wearable Systems