Publication

Direct Alkynylation of Indole and Pyrrole Heterocycles

Jérôme Waser, Jonathan Brand
2009
Journal Articles

Abstract

Easy does it: The unique properties of benziodoxolone alkynyl periodinane 1 and gold catalysts have allowed the development of a high yielding, operationally simple (room temperature, no dry solvents or inert conditions, commercially available catalyst) reaction for the introduction of silylacetylenes on a large range of indole and pyrrole heterocycles with a wide range of functional groups (see scheme).

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Direct Alkynylation of Indole and Pyrrole Heterocycles

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