Publications related to Multi-modal retinal imaging platform

In Vivo Retinal Pigment Epithelium Imaging using Transscleral Optical Imaging in Healthy Eyes

Christophe Moser, Mathieu Künzi, Timothé Laforest, Laura Emmanuelle Kowalczuk

Objective: To image healthy retinal pigment epithelial (RPE) cells in vivo using Transscleral OPtical Imaging (TOPI) and to analyze statistics of RPE cell features as a function of age, axial length (AL), and eccentricity. Design: Single-center, explorator ...

ELSEVIER2022

Homogeneous light stimulation of melanopsin and cones with a Maxwellian view device for the human eye

Gilles Evéquoz, Patrick Robert Flückiger

We designed and tested a device to stimulate specifically one photoreceptor type, or a combination of some of them, of the human eye by using up to six primaries. The device produces a homogeneous light field over 40 degrees which is projected onto the ret ...

IEEE2021

Ophthalmic system and method for clinical device using transcleral illumination with multiple points source

Christophe Moser, Mathieu Künzi, Timothé Laforest

An ophthalmic illumination and imaging system with transscleral / transpalpebral illumination of the eye fundus comprises a light-delivering device with a plurality of emitting areas; each of the emitting areas being configured to be independently controll ...

2020

3-Dimensional magnetic resonance imaging of the freely moving human eye

Jérôme Yerly, Silvio Ionta, Josefina Adriana Maria Bastiaansen, David Zeugin, João Pedro Forjaco Jorge, Benedetta Franceschiello, Lorenzo Di Sopra

Eye motion is a major confound for magnetic resonance imaging (MRI) in neuroscience or ophthalmology. Currently, solutions toward eye stabilisation include participants fixating or administration of paralytics/anaesthetics. We developed a novel MRI protoco ...

PERGAMON-ELSEVIER SCIENCE LTD2020

Eye Thought You Were Sick! Exploring Eye Behaviors for Cybersickness Detection in VR

Ronan Boulic, Nana Tian

Cybersickness induced through Virtual Reality (VR) applications is still one of its main barriers as it can induce unwanted side-effects in players, significantly hindering the overall experience. Despite the wealth of research available on this topic, it ...

ACM2020

Optical phase contrast imaging of human retinal cells by changing the tissue refractive index

Christophe Moser, Mathieu Künzi, Timothé Laforest, Laura Emmanuelle Kowalczuk

Purpose : Based on oblique partially coherent illumination of transparent samples, we developed a simple custom Optical Phase Imaging (OPI) microscope providing a label-free, semi-quantitative phase contrast imaging. The aim of this study was to explore th ...

ASSOC RESEARCH VISION OPHTHALMOLOGY INC2020

Ocular Structures Segmentation from Multi-sequences MRI Using 3D Unet with Fully Connected CRFs

Alessia Pica, Meritxell Bach Cuadra, Raphael Sznitman

The use of 3D Magnetic Resonance Imaging (MRI) has attracted growing attention for the purpose of diagnosis and treatment planning of intraocular ocular cancers. Precise segmentation of such tumors are highly important to characterize tumors, their progres ...

SPRINGER INTERNATIONAL PUBLISHING AG2018

Personalized Anatomic Eye Model From T1-Weighted Volume Interpolated Gradient Echo Magnetic Resonance Imaging of Patients With Uveal Melanoma

Alessia Pica, Meritxell Bach Cuadra, Raphael Sznitman

Purpose: We present a 3-dimensional patient-specific eye model from magnetic resonance imaging (MRI) for proton therapy treatment planning of uveal melanoma (UM). During MRI acquisition of UM patients, the point fixation can be difficult and, together with ...

ELSEVIER SCIENCE INC2018

Robust Eye Tracking Based on Adaptive Fusion of Multiple Cameras

Nuri Murat Arar

Eye and gaze movements play an essential role in identifying individuals' emotional states, cognitive activities, interests, and attention among other behavioral traits. Besides, they are natural, fast, and implicitly reflect the targets of interest, which ...

EPFL2017

System, method and apparatus for retinal absorption phase and dark field imaging with oblique illumination

Christophe Moser, Mathieu Künzi, Dino Carpentras, Timothé Laforest

A method for imaging a tissue of an eye, the method including the steps of providing oblique illumination to the eye by a plurality of light emitting areas of a light delivery device, the plurality of light emitting areas being independently controllable a ...

2017

Bosonic lasing and trapping of a dressed photon fluid in InGaN at room temperature

Munise Nevin Cobet

The generation of a quantum fluid of dressed photons at room temperature is experimentally demonstrated in an InGaN microcavity which is divided into two-and one-dimensional sections, resulting in single- and switchable multilevel coherent light emission. ...

Amer Physical Soc2016

Landmark Detection for Fusion of Fundus and MRI Toward a Patient-Specific Multimodal Eye Model

Meritxell Bach Cuadra, Carlos Ciller

Ophthalmologists typically acquire different image modalities to diagnose eye pathologies. They comprise, e.g., Fundus photography, optical coherence tomography, computed tomography, and magnetic resonance imaging (MRI). Yet, these images are often complem ...

Ieee-Inst Electrical Electronics Engineers Inc2015

A small-scale hyperacute compound eye featuring active eye tremor: application to visual stabilization, target tracking, and short-range odometry

Dario Floreano

In this study, a miniature artificial compound eye (15 mm in diameter) called the curved artificial compound eye (CurvACE) was endowed for the first time with hyperacuity, using similar micro-movements to those occurring in the fly's compound eye. A period ...

Iop Publishing Ltd2015

Cone-Rod Dystrophy Caused by a Novel Homozygous RPE65 Mutation in Leber Congenital Amaurosis

Background: The aim of this study was to describe an unexpected phenotype in a family with Leber congenital amaurosis (LCA) due to a retinal pigment epithelium-specific protein 65 kDa (RPE65) homozygous mutation. History and Signs: We analyzed a family fro ...

Georg Thieme Verlag Kg2014

Notch Signaling in Pigment Cells and Generation of Mouse Models for Ocular Diseases

Bhushan Sarode

Cellular signaling mediated by Notch receptors results in coordinated regulation of cell growth, survival and differentiation. In melanocytes, Notch signaling is essential for the maintenance of melanocytes and the melanocyte stem cell population. Whereas, ...

EPFL2013

ALDH1A3 loss of function causes bilateral anophthalmia/microphthalmia and hypoplasia of the optic nerve and optic chiasm

The major active retinoid, all-trans retinoic acid, has long been recognized as critical for the development of several organs, including the eye. Mutations in STRA6, the gene encoding the cellular receptor for vitamin A, in patients with MatthewWood syndr ...

Oxford University Press2013

A novel homozygous R764H mutation in crumbs homolog 1 causes autosomal recessive retinitis pigmentosa

Purpose: Retinitis pigmentosa (RP; MIM 268000) is a hereditary disease characterized by poor night vision and progressive loss of photoreceptors, eventually leading to blindness. This degenerative process primarily affects peripheral vision due to the loss ...

Molecular Vision2013

Simulation-based evaluation of non-visual responses to daylight: proof-of-concept study of healthcare re-design

Marilyne Andersen, María Lovísa Ámundadóttir, Steven W. Lockley

The discovery of a novel non-rod, non-cone photoreceptor in the human eye that mediates a number of effects on the brain has sparked a growing interest in incorporating these non-visual effects of light into the design process of buildings. Appropriately–t ...

2013

3D simulation of the aqueous flow in the human eye

Nikolaos Stergiopoulos, Philippe Reymond, Sylvain Roy, Adan Villamarin, Reda Hasballa, Orestis Vardoulis

Glaucoma results in an increase in the resistance of the aqueous humor outflow, which in turn leads to an increase of the intraocular pressure (IOP). Several treatments are proposed to reduce and stabilize the IOP that include medications, filtering surger ...

Elsevier Sci Ltd2012

Double Concentric Autofluorescence Ring in NR2E3-p.G56R-Linked Autosomal Dominant Retinitis Pigmentosa

Pascal Escher

PURPOSE. We reported an unusual appearance of fundus autofluorescence (FAF) associated with NR2E3-p.G56R-linked autosomal dominant retinitis pigmentosa (ADRP). METHODS. Patients were enrolled among three generations in a Swiss family. Molecular diagnosis i ...

Assoc Research Vision Ophthalmology Inc2012