Publication

Ceramic hydroxyapatite: a new tool for separation and analysis of IgA monoclonal antibodies

Urs von Stockar, Ian William Marison
1997
Conference Papers

Abstract

A novel downstream process is reported for preparative scale prodn. of dimeric IgA, a protein with potential pharmaceutical applications. Time-consuming size exclusion chromatog. was replaced by ceramic hydroxyapatite chromatog. (CHT). A clear baseline sepn. of the dimeric IgA from the polymeric forms using a step-gradient-step protein elution program is described. Application of this method for IgA anal. during prodn. is suggested. [on SciFinder (R)]

Official source

https://infoscience.epfl.ch/entities/publication/78ca5162-3df3-4046-8c4c-3b9a8b71a76f

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Urs von Stockar, Ian William Marison
1997
Conference Papers

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/78ca5162-3df3-4046-8c4c-3b9a8b71a76f

About this result

Related concepts (22)

Polymer

A polymer (ˈpɒlᵻmər; Greek poly-, "many" + -mer, "part") is a substance or material consisting of very large molecules called macromolecules, composed of many repeating subunits. Due to their broad spectrum of properties, both synthetic and natural polymers play essential and ubiquitous roles in everyday life. Polymers range from familiar synthetic plastics such as polystyrene to natural biopolymers such as DNA and proteins that are fundamental to biological structure and function.

Polymerization

In polymer chemistry, polymerization (American English), or polymerisation (British English), is a process of reacting monomer molecules together in a chemical reaction to form polymer chains or three-dimensional networks. There are many forms of polymerization and different systems exist to categorize them. In chemical compounds, polymerization can occur via a variety of reaction mechanisms that vary in complexity due to the functional groups present in the reactants and their inherent steric effects.

Protein

Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific 3D structure that determines its activity.

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Ceramic hydroxyapatite: a new tool for separation and analysis of IgA monoclonal antibodies

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