Publication

The simultaneous in-situ generation of aldehydes and phosphorus ylides. A convenient multi-step one-pot olefination protocol

Manfred Schlosser
1999
Journal Articles

Abstract

Li a-(dimethylamino)alkoxides resulting from the nucleophilic addn. of an organolithium reagent to DMF are basic enough to deprotonate alkyltriphenylphosphonium salts suspended in THF. The aldehydes, liberated by the spontaneous decompn. of the resulting a-amino alcs. (hemi-aminals), undergo a Wittig reaction with the simultaneously generated P ylides to afford olefins in excellent overall yields. This in situ method offers the unique advantage in its applicability to labile aldehydes which otherwise would become prey to (Z/E)-isomerization or self-condensation processes. [on SciFinder (R)]

Official source

https://infoscience.epfl.ch/entities/publication/7844c22f-8ae1-4665-874f-1f2ecdeaae98

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Manfred Schlosser
1999
Journal Articles

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/7844c22f-8ae1-4665-874f-1f2ecdeaae98

About this result

Related concepts (10)

Chromatin

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