Publication

Scan-based fusion proteins for modulating gene expression and methods of use

Didier Trono, Martina Begnis
2025

Abstract

The invention provides fusion protein comprising a SCAN domain bearing member of a zinc finger-containing protein, a fragment or variant thereof and a catalytically inactive RNA- guided endonuclease or a DNA adenine methyltransferase. Preferably, the fusion protein is for use in the treatment and/or prevention of cancer, neurodegenerative disease, neurodevelopmental disease, aging and aging-related disease.

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Scan-based fusion proteins for modulating gene expression and methods of use

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