Publication

Hydrogel viscoelasticity: identification of dissipation sources

Dominique Pioletti, Arne Christian Vogel
2008
Student Projects

Abstract

Intervertebral disc (IVD) degeneration is one of the prevailing medical concern and actual health cost. Industries and academic institutions research for therapeutic solutions going from drugs to complete and partial arthroplasty devices as well as engineered tissues. Nucleus pulposus replacement devices (NPRD), and particularly promising hydrogels, are being developed to restore the ``physiological'' state of the intervertebral disc. This project consists in investigating viscoelastic properties of hydrogels immersed in different solutions and at finite deformations. These investigations combined with appropriate mixture theory constitutive modelling should reveal relevant correlations between viscoelastic properties and biochemical information. The aim of the study is to address the major mechanical dissipation sources inherent to the material.

Official source

https://infoscience.epfl.ch/entities/publication/7748641d-cb13-4465-a083-0e642f35976f

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Dominique Pioletti, Arne Christian Vogel
2008
Student Projects

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/7748641d-cb13-4465-a083-0e642f35976f

About this result

Related concepts (30)

Tissue engineering

Tissue engineering is a biomedical engineering discipline that uses a combination of cells, engineering, materials methods, and suitable biochemical and physicochemical factors to restore, maintain, improve, or replace different types of biological tissues. Tissue engineering often involves the use of cells placed on tissue scaffolds in the formation of new viable tissue for a medical purpose but is not limited to applications involving cells and tissue scaffolds.

Hydrogel

A hydrogel is a biphasic material, a mixture of porous, permeable solids and at least 10% by weight or volume of interstitial fluid composed completely or mainly by water. In hydrogels the porous permeable solid is a water insoluble three dimensional network of natural or synthetic polymers and a fluid, having absorbed a large amount of water or biological fluids. These properties underpin several applications, especially in the biomedical area. Many hydrogels are synthetic, but some are derived from nature.

Gel

A gel is a semi-solid that can have properties ranging from soft and weak to hard and tough. Gels are defined as a substantially dilute cross-linked system, which exhibits no flow when in the steady-state, although the liquid phase may still diffuse through this system. A gel has been defined phenomenologically as a soft, solid or solid-like material consisting of two or more components, one of which is a liquid, present in substantial quantity.

Related publications (4)

Hydrogel viscoelasticity: identification of dissipation sources

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