Publication

Site Selective Functionalization of Fluorinated Nitrogen Heterocycles

Manfred Schlosser
2009
Book Chapters

Abstract

Functional groups are prerequisites for the assembly of building blocks to more elaborate structures for research work in the life sciences field. Functionalization can be most conveniently and efficaciously accomplished by generating an organometallic deriv. of the arom. or heterocyclic starting material and subsequently treating it with the electrophile of choice. The presence of heterosubstituents facilitates immensely the introduction of the metal (by permutational halogen/metal or hydrogen/metal interconversion) and at the same time enables a perfect control of the desired regioselectivity as will be illustrated by typical examples selected from the indole, pyrazoles, pyridine and quinoline fields.

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https://infoscience.epfl.ch/entities/publication/77022f87-6b5e-4568-b20e-493b0ca6bca6

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Manfred Schlosser
2009
Book Chapters

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/77022f87-6b5e-4568-b20e-493b0ca6bca6

About this result

Related concepts (22)

Functional group

In organic chemistry, a functional group is a substituent or moiety in a molecule that causes the molecule's characteristic chemical reactions. The same functional group will undergo the same or similar chemical reactions regardless of the rest of the molecule's composition. This enables systematic prediction of chemical reactions and behavior of chemical compounds and the design of chemical synthesis. The reactivity of a functional group can be modified by other functional groups nearby.

Nucleophile

In chemistry, a nucleophile is a chemical species that forms bonds by donating an electron pair. All molecules and ions with a free pair of electrons or at least one pi bond can act as nucleophiles. Because nucleophiles donate electrons, they are Lewis bases. Nucleophilic describes the affinity of a nucleophile to bond with positively charged atomic nuclei. Nucleophilicity, sometimes referred to as nucleophile strength, refers to a substance's nucleophilic character and is often used to compare the affinity of atoms.

Electrophile

In chemistry, an electrophile is a chemical species that forms bonds with nucleophiles by accepting an electron pair. Because electrophiles accept electrons, they are Lewis acids. Most electrophiles are positively charged, have an atom that carries a partial positive charge, or have an atom that does not have an octet of electrons. Electrophiles mainly interact with nucleophiles through addition and substitution reactions.