Publications related to The Pollutant Diethylhexyl Phthalate Regulates Hepatic Energy Metabolism via Species-Specific PPAR alpha-Dependent Mechanisms

Related publications (16)

Size-related variability of oxygen consumption rates in individual human hepatic cells

Accurate descriptions of the variability in single-cell oxygen consumption and its size-dependency are key to establishing more robust tissue models. By combining microfabricated devices with multiparameter identification algorithms, we demonstrate that si ...

2024

Repeated Human Exposure to Semivolatile Organic Compounds by Inhalation: Novel Protocol for a Nonrandomized Study

Dominique Grandjean, Florian Frédéric Vincent Breider, Guillaume Suarez

Background: Semivolatile organic compounds (SVOCs) comprise several different chemical families used mainly as additives in many everyday products. SVOCs can be released into the air as aerosols and deposit on particulate matter during use by dispersion, e ...

2023

Photodegradation of biodegradable plastics in aquatic environments: Current understanding and challenges

Florian Frédéric Vincent Breider

Direct photolysis and indirect photolysis are important abiotic processes in aquatic environments through which plastics can be transformed physically and chemically. Transport of biodegradable plastics in water is influenced by vertical mixing and turbule ...

2023

Photobiology and metabolic interactions in the symbiotic jellyfish Cassiopea

Niclas Heidelberg Lyndby

The symbiont-bearing jellyfish Cassiopea live a benthic lifestyle, positioning themselves upside-down on sediments in shallow waters to allow their endosymbiotic algae to photosynthesize in the sunlight. Over the last decades Cassiopea has become increasin ...

EPFL2023

Integrative systems analysis identifies genetic and dietary modulators of bile acid homeostasis

Kristina Schoonjans, Johan Auwerx, Alexis Maximilien Bachmann, Maroun Bou Sleiman, Alessia Perino, Amir Banaei Esfahani, Karim Laurent Gariani, Giacomo Vincenzo Giorgio Von Alvensleben, Hao Li, Qingyao Huang, Laura Alejandra Velazquez Villegas, Yu Sun, Xiaoxu Li, Ludger Jan Elzuë Goeminne, Jéromine Imbach

Bile acids (BAs) are complex and incompletely understood enterohepatic-derived hormones that control whole-body metabolism. Here, we profiled postprandial BAs in the liver, feces, and plasma of 360 chowor high-fat-diet-fed BXD male mice and demonstrated th ...

Cell Press2022

Inhibition of sphingolipid de novo synthesis counteracts muscular dystrophy

Johan Auwerx, Peiling Luan, Pirkka-Pekka Untamo Laurila, Martin Rainer Wohlwend, Ludger Jan Elzuë Goeminne, Tanes Imamura de Lima

Duchenne muscular dystrophy (DMD), the most common muscular dystrophy, is a severe muscle disorder, causing muscle weakness, loss of independence, and premature death. Here, we establish the link between sphingolipids and muscular dystrophy. Transcripts of ...

2022

AMP-activated Protein Kinase (AMPK): New molecular insights and novel downstream targets

Katyayanee Neopane

AMP-activated Protein Kinase (AMPK) is a central regulator of energy homeostasis and a promising drug target for metabolic disorders. It exists as complexes of three subunits, a catalytic alpha, and two regulatory beta and gamma subunits. The regulation of ...

EPFL2022

Algal cellulose, production and potential use in plastics: Challenges and opportunities

Horst Pick, Christian Ludwig, Adrian Pulgarin, Enio Daniel Zanchetta, Eya Nicodeme, Tobias Borgmeyer

The development of new biodegradable plastic materials from renewable sources is a major challenge for plastic industries to provide sustainable alternatives to petroleum plastic. Bio-based plastics are generally obtained from photosynthetic biomass such a ...

2021

Inferring the flow properties of epithelial tissues from their geometry

Marko Popovic, Matthieu Wyart

Amorphous materials exhibit complex material properties with strongly nonlinear behaviors. Below a yield stress they behave as plastic solids, while they start to yield above a critical stress sigma(c). A key quantity controlling plasticity which is, howev ...

2021

Plastic pollution in Swiss surface waters: nature and concentrations, interaction with pollutants

Luiz Felippe De Alencastro, Florian Faure, Colin Demars

Marine microplastic (,5 mm) water pollution has met growing public and scientific interest in the last few years. The situation in freshwater environments remains largely unknown, although it appears that they play an important role as part of the origin o ...

Csiro Publishing2015

Dissociating effect of upper limb non-use and overuse on space and body representations

Andrea Serino, Elisa Canzoneri, Michela Bassolino

Accurate and updated representations of the space where the body acts, i.e. the peripersonal space (PPS), and the location and dimension of body parts (body representation, BR) are essential to perform actions. Because both PPS and BR are involved in motor ...

Pergamon-Elsevier Science Ltd2015

The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation

Kristina Schoonjans, Johan Auwerx, Lilia Noriega Lopez, Mitsunori Nomura, Thijs Pols

Bile acids (BAs) are amphipathic molecules that facilitate the uptake of lipids, and their levels fluctuate in the intestine as well as in the blood circulation depending on food intake. Besides their role in dietary lipid absorption, bile acids function a ...

Elsevier2011

Novel luminescent Ir(III) dyes for developing highly sensitive oxygen sensing films

Michael Graetzel, Mohammad Khaja Nazeeruddin

New sensing films have been developed for the detection of molecular oxygen. These films are based on luminescent Ir(III) dyes incorporated either into polystyrene (with and without plasticizer) or metal oxide, nanostructured material. The preparation and ...

Elsevier2010

PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure

Johan Auwerx, Carlos Canto Alvarez

PURPOSE OF REVIEW: Peroxisome proliferator-activated receptor gamma coactivator-1-alpha (PGC-1alpha) has been extensively described as a master regulator of mitochondrial biogenesis. However, PGC-1alpha activity is not constant and can be finely tuned in r ...

2009

Interaction sol-structure dans le domaine des tranchées couvertes

Sylvain Plumey

The present research on cut-and-cover tunnels gives a theoretical contribution to the understanding of the behaviour of these structures up to their ultimate limit state. A simplified method inspired on the convergence-confinement method is investigated an ...

EPFL2007

Plasticity and geophysical flows: A review

Christophe Ancey

The objective of this review is to examine how the concept of plasticity is used in geophysical fluid dynamics. Rapid mass movements such as snow avalanches or debris flows involve slurries of solid particles (ice, boulder, clay, etc.) within an interstiti ...

2007