Publication

Synthetic helical polypeptide models the acetylcholine receptor channel function

Horst Arthur Vogel
1989
Conference Papers

Abstract

A review with 11 refs. on a fluorescent Aib-contg. peptide model for the acetylcholine receptor ion channel. This peptide induces single-channel conductance in planar lipid bilayers exhibiting one single open conductance state and weakly voltage-dependent kinetics. The peptides fluorescent dansyl group can be used to correlate motions of the peptide helix with channel opening and closing. [on SciFinder (R)]

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Horst Arthur Vogel
1989
Conference Papers

Abstract

Official source

Related concepts (32)

Nicotinic acetylcholine receptor

Nicotinic acetylcholine receptors, or nAChRs, are receptor polypeptides that respond to the neurotransmitter acetylcholine. Nicotinic receptors also respond to drugs such as the agonist nicotine. They are found in the central and peripheral nervous system, muscle, and many other tissues of many organisms. At the neuromuscular junction they are the primary receptor in muscle for motor nerve-muscle communication that controls muscle contraction.

Ligand-gated ion channel

Ligand-gated ion channels (LICs, LGIC), also commonly referred to as ionotropic receptors, are a group of transmembrane ion-channel proteins which open to allow ions such as Na+, K+, Ca2+, and/or Cl− to pass through the membrane in response to the binding of a chemical messenger (i.e. a ligand), such as a neurotransmitter. When a presynaptic neuron is excited, it releases a neurotransmitter from vesicles into the synaptic cleft. The neurotransmitter then binds to receptors located on the postsynaptic neuron.

Muscarinic acetylcholine receptor

Muscarinic acetylcholine receptors, or mAChRs, are acetylcholine receptors that form G protein-coupled receptor complexes in the cell membranes of certain neurons and other cells. They play several roles, including acting as the main end-receptor stimulated by acetylcholine released from postganglionic fibers in the parasympathetic nervous system. Muscarinic receptors are so named because they are more sensitive to muscarine than to nicotine.

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Synthetic helical polypeptide models the acetylcholine receptor channel function

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