A mitochondria-specific mutational signature of aging: increased rate of A > G substitutions on the heavy strand

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BackgroundAging in postmitotic tissues is associated with clonal expansion of somatic mitochondrial deletions, the origin of which is not well understood. Such deletions are often flanked by direct nucleotide repeats, but this alone does not fully explain ...

The resilience of the mitochondrial genome (mtDNA) to a high mutational pressure depends, in part, on negative purifying selection in the germline. A paradigm in the field has been that such selection, at least in part, takes place in primordial germ cells ...

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A mitochondria-specific mutational signature of aging: increased rate of A > G substitutions on the heavy strand

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