Publications related to AXIN1 knockout does not alter AMPK/mTORC1 regulation and glucose metabolism in mouse skeletal muscle

Related publications (6)

A locally activatable sensor for robust quantification of organellar glutathione

Glutathione (GSH) is the main determinant of intracellular redox potential and participates in multiple cellular signalling pathways. Achieving a detailed understanding of intracellular GSH homeostasis depends on the development of tools to map GSH compart ...

NATURE PORTFOLIO2023

Inhibition of sphingolipid de novo synthesis counteracts muscular dystrophy

Johan Auwerx, Peiling Luan, Pirkka-Pekka Untamo Laurila, Martin Rainer Wohlwend, Ludger Jan Elzuë Goeminne, Tanes Imamura de Lima

Duchenne muscular dystrophy (DMD), the most common muscular dystrophy, is a severe muscle disorder, causing muscle weakness, loss of independence, and premature death. Here, we establish the link between sphingolipids and muscular dystrophy. Transcripts of ...

2022

Paradoxical neuronal hyperexcitability in a mouse model of mitochondrial pyruvate import deficiency

Maria del Carmen Sandi Perez, Simone Astori, Eva Ramos Fernandez

Neuronal excitation imposes a high demand of ATP in neurons. Most of the ATP derives primarily from pyruvate-mediated oxidative phosphorylation, a process that relies on import of pyruvate into mitochondria occuring exclusively via the mitochondrial pyruva ...

eLIFE SCIENCES PUBL LTD2022

Integrative systems analysis identifies genetic and dietary modulators of bile acid homeostasis

Kristina Schoonjans, Johan Auwerx, Alexis Maximilien Bachmann, Maroun Bou Sleiman, Alessia Perino, Amir Banaei Esfahani, Karim Laurent Gariani, Giacomo Vincenzo Giorgio Von Alvensleben, Hao Li, Qingyao Huang, Laura Alejandra Velazquez Villegas, Yu Sun, Xiaoxu Li, Ludger Jan Elzuë Goeminne, Jéromine Imbach

Bile acids (BAs) are complex and incompletely understood enterohepatic-derived hormones that control whole-body metabolism. Here, we profiled postprandial BAs in the liver, feces, and plasma of 360 chowor high-fat-diet-fed BXD male mice and demonstrated th ...

Cell Press2022

Glucose Monitoring Using a Polymer Brush Modified Polypropylene Hollow Fiber-based Hydraulic Flow Sensor

Harm-Anton Klok, Nicolas Fortin

Tight regulation of blood glucose levels of diabetic patients requires durable and robust continuous glucose sensing schemes. This manuscript reports the fabrication of ultrathin, phenylboronic acid (PBA) functionalized polymer brushes that swell upon gluc ...

Amer Chemical Soc2015

Advanced Fluorescence Microscopy to Study Plasma Membrane Protein Dynamics

Joachim Piguet

Membrane protein dynamics is of great importance for living organisms. The precise localization of proteins composing a synapse on the membrane facing a nerve terminus is essential for proper functioning of the nervous system. In muscle fibers, the nicotin ...

EPFL2010