Publication

Longitudinal analysis of brain network reorganization in preterm IUGR children at 1, 6 and 9 years-old

Jean-Philippe Thiran
2014
Conference Papers

Abstract

Intrauterine Growth Restriction (IUGR) due to placental insufficiency affects 5-10% of all pregnancies and it is associated with a wide range of short and long-term neurodevelopmental disorders. Different approaches have been considered to understand IUGR effects on brain development. Recently, connectomics has been used to analyze brain reorganization in IUGR children at one and six years of age. Connectomics estimates the brain network and describes it by different graph measures. Diffusion tensor imaging (DTI) can be used to infer the connectivity between regions, since it allows in-vivo estimation of fiber tracts inside the brain. In this study, DTI based connectomics was used to describe short- and long-term brain reorganization in IUGR. The connectome of a cohort of preterm IUGR and control children at 1, 6 and 9 years of age was estimated and analyzed to evaluate differences in the architecture of neural circuitry and its evolution during development.

Official source

https://infoscience.epfl.ch/entities/publication/72d1a349-5c5c-4a24-b527-1f409bff621f

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Jean-Philippe Thiran
2014
Conference Papers

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/72d1a349-5c5c-4a24-b527-1f409bff621f

About this result

Related concepts (32)

Brain

A brain is an organ that serves as the center of the nervous system in all vertebrate and most invertebrate animals. It is located in the head, usually close to the sensory organs for senses such as vision. It is the most complex organ in a vertebrate's body. In a human, the cerebral cortex contains approximately 14–16 billion neurons, and the estimated number of neurons in the cerebellum is 55–70 billion. Each neuron is connected by synapses to several thousand other neurons.

Connectomics

Connectomics is the production and study of connectomes: comprehensive maps of connections within an organism's nervous system. More generally, it can be thought of as the study of neuronal wiring diagrams with a focus on how structural connectivity, individual synapses, cellular morphology, and cellular ultrastructure contribute to the make up of a network. The nervous system is a network made of billions of connections and these connections are responsible for our thoughts, emotions, actions, memories, function and dysfunction.

Human brain

The human brain is the central organ of the human nervous system, and with the spinal cord makes up the central nervous system. The brain consists of the cerebrum, the brainstem and the cerebellum. It controls most of the activities of the body, processing, integrating, and coordinating the information it receives from the sense organs, and making decisions as to the instructions sent to the rest of the body. The brain is contained in, and protected by, the skull bones of the head.

Related publications (32)

Longitudinal analysis of brain network reorganization in preterm IUGR children at 1, 6 and 9 years-old

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