Bimodal control of Hoxd gene transcription in the spinal cord defines two regulatory subclusters

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Here the authors show that a strong enhancer sequence can be controlled by the chromatin environment provided by a topologically associated domain (TAD) located nearby. An enhancer relocated by homologous recombination takes all the hallmarks of its new ne ...

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Binding to binding site clusters has yet to be characterized in depth, and the functional relevance of low-affinity clusters remains uncertain. We characterized transcription factor binding to low-affinity clusters in vitro and found that transcription fac ...

Bimodal control of Hoxd gene transcription in the spinal cord defines two regulatory subclusters

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