The helical content of the YscP molecular ruler determines the length of the Yersinia injectisome

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BackgroundStatistical potentials, also named knowledge-based potentials, are scoring functions derived from empirical data that can be used to evaluate the quality of protein folds and protein-protein interaction (PPI) structures. In previous works we deco ...

The work presented in this thesis combines supervised and unsupervised machine learning to examine structure-property relationships in databases of materials. While either supervised learning or unsupervised learning alone can be a powerful tool for assess ...

Granular hydrogels with high stability, strength, and toughness are laborious to develop. Post-curing is often employed to bind microgels chemically and enhance mechanical properties. Here a unique strategy was investigated to maintain microgels together w ...

Glutamate dehydrogenases (GDHs) are widespread metabolic enzymes that play key roles in nitrogen homeostasis. Large glutamate dehydrogenases composed of 180kDa subunits (L-GDHs(180)) contain long N- and C-terminal segments flanking the catalytic core. Desp ...

Structure-based antibody and antigen design has advanced greatly in recent years, due not only to the increasing availability of experimentally determined structures but also to improved computational methods for both prediction and design. Constant improv ...

The true understanding of most cellular functions is only really achievable through the structural determination of their underlying macromolecular assemblies. However, their size, large number of individual components and metastable states make their eluc ...

De novo protein design has enabled the creation of new protein structures. However, the design of functional proteins has proved challenging, in part due to the difficulty of transplanting structurally complex functional sites to available protein structur ...

Student-teacher relationships play an important role in both teacher and student experiences in higher education and have been found to be linked to learning, classroom management, and to student absenteeism. Although historically conceptualised in terms o ...

The helical content of the YscP molecular ruler determines the length of the Yersinia injectisome

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SPServer: split-statistical potentials for the analysis of protein structures and protein-protein interactions

Structure-Property Relationships in Complex Materials by Combining Supervised and Unsupervised Machine Learning

Silk granular hydrogels self-reinforced with regenerated silk fibroin fibers

3D architecture and structural flexibility revealed in the subfamily of large glutamate dehydrogenases by a mycobacterial enzyme

Modeling Immunity with Rosetta: Methods for Antibody and Antigen Design

New Methods for the Integrative Dynamic Modeling of Biomolecular Structures

Bottom-up de novo design of functional proteins with complex structural features

Rethinking student-teacher relationships in higher education: a multidimensional approach