Publication

Dual limitations. Kinetic and stoichiometric analysis

Urs von Stockar
1998
Journal Articles

Abstract

Although a rigorous definition of growth-limiting substrate relies on a kinetic anal., a simple stoichiometric anal. based on the calcn. of the conversion is more applicable. Anal. of single and dual limitations is based on a simulated example for a substrate taken-up by facilitated diffusion (e.g. glucose) or by free diffusion (e.g. ethanol) and shows that a kinetic single or dual limitation can usually be predicted by comparing the conversion of two nutrients with the expected stoichiometry. Stoichiometric anal. of dual limitations is applied to exptl. data for Kluyveromyces marxianus (for glucose and oxygen) and Saccharomyces cerevisiae (for glucose and ammonium). [on SciFinder (R)]

Official source

https://infoscience.epfl.ch/entities/publication/723ce6a6-231a-45df-8dc0-807f5c25320d

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Urs von Stockar
1998
Journal Articles

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/723ce6a6-231a-45df-8dc0-807f5c25320d

About this result

Related concepts (19)

Facilitated diffusion

Facilitated diffusion (also known as facilitated transport or passive-mediated transport) is the process of spontaneous passive transport (as opposed to active transport) of molecules or ions across a biological membrane via specific transmembrane integral proteins. Being passive, facilitated transport does not directly require chemical energy from ATP hydrolysis in the transport step itself; rather, molecules and ions move down their concentration gradient reflecting its diffusive nature.

Diffusion

Diffusion is the net movement of anything (for example, atoms, ions, molecules, energy) generally from a region of higher concentration to a region of lower concentration. Diffusion is driven by a gradient in Gibbs free energy or chemical potential. It is possible to diffuse "uphill" from a region of lower concentration to a region of higher concentration, like in spinodal decomposition. Diffusion is a stochastic process due to the inherent randomness of the diffusing entity and can be used to model many real-life stochastic scenarios.

Passive transport

Passive transport is a type of membrane transport that does not require energy to move substances across cell membranes. Instead of using cellular energy, like active transport, passive transport relies on the second law of thermodynamics to drive the movement of substances across cell membranes. Fundamentally, substances follow Fick's first law, and move from an area of high concentration to one of low concentration because this movement increases the entropy of the overall system.

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Dual limitations. Kinetic and stoichiometric analysis

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