A platform for experimental precision medicine: The extended BXD mouse family

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Related publications (28)

Pressure on obstacles induced by granular snow avalanches

The increasing population and the consequential demand for dwelling and recreation areas lead to more frequent conflicts between humans and natural hazards. In mountainous regions snow avalanches are, therefore, still a major threat to humans and infrastru ...

EPFL2021

A fully joint Bayesian quantitative trait locus mapping of human protein abundance in plasma

Anthony Christopher Davison, Hélène Ruffieux, Radu Popescu, Jörg Hager

Molecular quantitative trait locus (QTL) analyses are increasingly popular to explore the genetic architecture of complex traits, but existing studies do not leverage shared regulatory patterns and suffer from a large multiplicity burden, which hampers the ...

PUBLIC LIBRARY SCIENCE2020

Comprehensive analysis of PM20D1 QTL in Alzheimer's disease

Liliane Glauser, Johannes Gräff, Jose Vicente Sanchez Mut

Background Alzheimer's disease (AD) is a complex disorder caused by a combination of genetic and non-genetic risk factors. In addition, an increasing evidence suggests that epigenetic mechanisms also accompany AD. Genetic and epigenetic factors are not ind ...

2020

cis-regulatory variation modulates susceptibility to enteric infection in the Drosophila genetic reference panel

Michael Vincent Frochaux, Bart Deplancke, Dani Osman, Maroun Bou Sleiman, Tommaso Andreani, Riccardo Dainese, Virginie Sandra Braman, Vincent Roland Julien Gardeux, Maria Litovchenko, Brian Dennis Hollis

Background: Resistance to enteric pathogens is a complex trait at the crossroads of multiple biological processes. We have previously shown in the Drosophila Genetic Reference Panel (DGRP) that resistance to infection is highly heritable, but our understan ...

2020

Critical review on bioconversion of winery wastes into value-added products

Edgard Gnansounou, Ranjna Sirohi

Global increase in the human population and life-style changes have led to enormous development in various industries, including beverage industry. Among the innumerable beverage industries, wineries have received increasing attention and consideration due ...

ELSEVIER2020

Cyclometalated Ir(III) complexes as tuneable multiband light sources for optical multisensor systems: Feasibility study

Anastasia Gitlina

Development of novel analytical devices complying with modern requirements of simplicity and cost-effectiveness is an important task. Multisensor systems based on various types of chemical sensors are promising tools in this respect. Herein the development ...

2020

Genetic spectrum of retinal dystrophies in Tunisia

Imen Habibi

We report the molecular basis of the largest Tunisian cohort with inherited retinal dystrophies (IRD) reported to date, identify disease-causing pathogenic variants and describe genotype-phenotype correlations. A subset of 26 families from a cohort of 73 f ...

Nature Research2020

Learning a Unified Blind Image Quality Metric via On-Line and Off-Line Big Training Instances

Daniel Thalmann, Xingyu Xu

In this work, we resolve a big challenge that most current image quality metrics (IQMs) are unavailable across different image contents, especially simultaneously coping with natural scene (NS) images or screen content (SC) images. By comparison with exist ...

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC2020

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