Publication

Catalytic Enantiospecific [3+2] Annulation of Aminocyclopropanes with Ketones

Jérôme Waser, Florian Patrick Marie Daniel De la Barre De Nanteuil, Fides Benfatti
2012
Journal Articles

Abstract

The first enantiospecific [3+2] annulation of D-A amino-cyclopropanes with ketones is reported herein (see scheme; Phth = phthaloyl). The reaction is catalyzed by 5 mol % of tin(IV) chloride at -78 °C and gives aminotetra-hydrofurans bearing a C5-quaternary stereocenter in high yield, diastereoselectivity and enantio-specificity.

Official source

https://infoscience.epfl.ch/entities/publication/6e99e15d-d750-482b-bad1-2a3fe8fee97a

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Catalytic Enantiospecific [3+2] Annulation of Aminocyclopropanes with Ketones

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