Publication

Accelerating Multi-Echo GRASE with CAIPIRINHA for Fast and High-Resolution Myelin Water Imaging

Jean-Philippe Thiran
2019
Posters

Abstract

Impaired myelin plays a central role in a wide range of degenerative brain diseases. A method for non-invasive and in vivo assessment of myelin content within clinically acceptable acquisition times is thus desirable. In this work, a 3D multi-echo gradient and spin-echo (GRASE) sequence was accelerated with CAIPIRINHA to achieve high-resolution and whole-brain myelin imaging in less than ten minutes. Myelin water fraction (MWF) maps were derived from multi-echo GRASE data in a cohort of healthy subjects and values proved to be consistent with MWF maps computed from a conventional multi-echo spin-echo acquisition.

Official source

https://infoscience.epfl.ch/entities/publication/6c0bc5f7-27de-4220-a21e-cc0f375dc840

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Jean-Philippe Thiran
2019
Posters

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/6c0bc5f7-27de-4220-a21e-cc0f375dc840

About this result

Related concepts (32)

Myelin

In most vertebrates (including humans), myelin is a lipid-rich material that surrounds nerve cell axons (the nervous system's "wires") to insulate them and increase the rate at which electrical impulses (called action potentials) are passed along the axon. The myelinated axon can be likened to an electrical wire (the axon) with insulating material (myelin) around it. However, unlike the plastic covering on an electrical wire, myelin does not form a single long sheath over the entire length of the axon.

Demyelinating disease

A demyelinating disease refers to any disease affecting the nervous system where the myelin sheath surrounding neurons is damaged. This damage disrupts the transmission of signals through the affected nerves, resulting in a decrease in their conduction ability. Consequently, this reduction in conduction can lead to deficiencies in sensation, movement, cognition, or other functions depending on the nerves affected. Various factors can contribute to the development of demyelinating diseases, including genetic predisposition, infectious agents, autoimmune reactions, and other unknown factors.

Diffusion MRI

Diffusion-weighted magnetic resonance imaging (DWI or DW-MRI) is the use of specific MRI sequences as well as software that generates images from the resulting data that uses the diffusion of water molecules to generate contrast in MR images. It allows the mapping of the diffusion process of molecules, mainly water, in biological tissues, in vivo and non-invasively. Molecular diffusion in tissues is not random, but reflects interactions with many obstacles, such as macromolecules, fibers, and membranes.

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