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Publication

Assessment of nanoparticles’ safety: corrected absorbance-based toxicity test

Heinrich Hofmann, Marijana Mionic Ebersold, Débora Bonvin
2017
Journal Articles

Abstract

We developed a method to correct absorbance-based toxicity tests to remove the influence of the deposited dose of nano-particles. As a model of absorbance-based toxicity tests, we chose the frequently used MTS test. The corrected cell viabilities obtained with the MTS test matched the results of the fluorescence-based PrestoBlue (R) test.

Official source

https://infoscience.epfl.ch/entities/publication/6b36533a-dffe-446b-a68b-e4890c8b8b79

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Heinrich Hofmann, Marijana Mionic Ebersold, Débora Bonvin
2017
Journal Articles

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/6b36533a-dffe-446b-a68b-e4890c8b8b79

About this result

Related concepts (8)

Absorbed dose

Absorbed dose is a dose quantity which is the measure of the energy deposited in matter by ionizing radiation per unit mass. Absorbed dose is used in the calculation of dose uptake in living tissue in both radiation protection (reduction of harmful effects), and radiology (potential beneficial effects, for example in cancer treatment). It is also used to directly compare the effect of radiation on inanimate matter such as in radiation hardening. The SI unit of measure is the gray (Gy), which is defined as one Joule of energy absorbed per kilogram of matter.

Dosimeter

A radiation dosimeter is a device that measures dose uptake of external ionizing radiation. It is worn by the person being monitored when used as a personal dosimeter, and is a record of the radiation dose received. Modern electronic personal dosimeters can give a continuous readout of cumulative dose and current dose rate, and can warn the wearer with an audible alarm when a specified dose rate or a cumulative dose is exceeded.

Sievert

The sievert (symbol: Sv) is a unit in the International System of Units (SI) intended to represent the stochastic health risk of ionizing radiation, which is defined as the probability of causing radiation-induced cancer and genetic damage. The sievert is important in dosimetry and radiation protection. It is named after Rolf Maximilian Sievert, a Swedish medical physicist renowned for work on radiation dose measurement and research into the biological effects of radiation.

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Assessment of nanoparticles’ safety: corrected absorbance-based toxicity test

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